Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia

Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety...

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Autores principales: Nicholas R. G. Silver, Rachel Ward-Flanagan, Clayton T. Dickson
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Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/e76a87226a2e42149a33e7a1d52211ab
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spelling oai:doaj.org-article:e76a87226a2e42149a33e7a1d52211ab2021-11-04T06:09:19ZLong-term stability of physiological signals within fluctuations of brain state under urethane anesthesia1932-6203https://doaj.org/article/e76a87226a2e42149a33e7a1d52211ab2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544839/?tool=EBIhttps://doaj.org/toc/1932-6203Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety of physiological and pathophysiological processes. As urethane is typically administered as a single-bolus dose, it is unclear the stability of peripheral physiological functions both within and between brain-states under urethane anesthesia. In this present study, we recorded respiration rate and heart rate concurrently with local field potentials from the neocortex and hippocampus to determine the stability of peripheral physiological functions within and between brain-states under urethane anesthesia. Our data shows electroencephalographic characteristics and breathing rate are remarkable stable over long-term recordings within minor reductions in heart rate on the same time scale. Our findings indicate that the use of urethane to model peripheral physiological functions associated with changing brain states are stable during long duration experiments.Nicholas R. G. SilverRachel Ward-FlanaganClayton T. DicksonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nicholas R. G. Silver
Rachel Ward-Flanagan
Clayton T. Dickson
Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
description Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety of physiological and pathophysiological processes. As urethane is typically administered as a single-bolus dose, it is unclear the stability of peripheral physiological functions both within and between brain-states under urethane anesthesia. In this present study, we recorded respiration rate and heart rate concurrently with local field potentials from the neocortex and hippocampus to determine the stability of peripheral physiological functions within and between brain-states under urethane anesthesia. Our data shows electroencephalographic characteristics and breathing rate are remarkable stable over long-term recordings within minor reductions in heart rate on the same time scale. Our findings indicate that the use of urethane to model peripheral physiological functions associated with changing brain states are stable during long duration experiments.
format article
author Nicholas R. G. Silver
Rachel Ward-Flanagan
Clayton T. Dickson
author_facet Nicholas R. G. Silver
Rachel Ward-Flanagan
Clayton T. Dickson
author_sort Nicholas R. G. Silver
title Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
title_short Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
title_full Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
title_fullStr Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
title_full_unstemmed Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
title_sort long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/e76a87226a2e42149a33e7a1d52211ab
work_keys_str_mv AT nicholasrgsilver longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia
AT rachelwardflanagan longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia
AT claytontdickson longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia
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