A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF...

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Autores principales:	Siobhan S. Pattwell, Sonali Arora, Patrick J. Cimino, Tatsuya Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, Benjamin G. Hoffstrom, Norman E. Boiani, Hamid Bolouri, Colin E. Correnti, Barbara Oldrini, John R. Silber, Massimo Squatrito, Patrick J. Paddison, Eric C. Holland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e76b737ec4c34d949cb32dc9395b4f44
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spelling	oai:doaj.org-article:e76b737ec4c34d949cb32dc9395b4f442021-12-02T14:59:27ZA kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways10.1038/s41467-020-16786-52041-1723https://doaj.org/article/e76b737ec4c34d949cb32dc9395b4f442020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16786-5https://doaj.org/toc/2041-1723Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF-driven gliomas in vivo and augments PI3K signaling cascades in vitro.Siobhan S. PattwellSonali AroraPatrick J. CiminoTatsuya OzawaFrank SzulzewskyPia HoellerbauerTobias BonifertBenjamin G. HoffstromNorman E. BoianiHamid BolouriColin E. CorrentiBarbara OldriniJohn R. SilberMassimo SquatritoPatrick J. PaddisonEric C. HollandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siobhan S. Pattwell Sonali Arora Patrick J. Cimino Tatsuya Ozawa Frank Szulzewsky Pia Hoellerbauer Tobias Bonifert Benjamin G. Hoffstrom Norman E. Boiani Hamid Bolouri Colin E. Correnti Barbara Oldrini John R. Silber Massimo Squatrito Patrick J. Paddison Eric C. Holland A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
description	Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF-driven gliomas in vivo and augments PI3K signaling cascades in vitro.
format	article
author	Siobhan S. Pattwell Sonali Arora Patrick J. Cimino Tatsuya Ozawa Frank Szulzewsky Pia Hoellerbauer Tobias Bonifert Benjamin G. Hoffstrom Norman E. Boiani Hamid Bolouri Colin E. Correnti Barbara Oldrini John R. Silber Massimo Squatrito Patrick J. Paddison Eric C. Holland
author_facet	Siobhan S. Pattwell Sonali Arora Patrick J. Cimino Tatsuya Ozawa Frank Szulzewsky Pia Hoellerbauer Tobias Bonifert Benjamin G. Hoffstrom Norman E. Boiani Hamid Bolouri Colin E. Correnti Barbara Oldrini John R. Silber Massimo Squatrito Patrick J. Paddison Eric C. Holland
author_sort	Siobhan S. Pattwell
title	A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
title_short	A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
title_full	A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
title_fullStr	A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
title_full_unstemmed	A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
title_sort	kinase-deficient ntrk2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e76b737ec4c34d949cb32dc9395b4f44
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A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

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