Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit

Abstract Enzymatic glucose biosensors are being developed to incorporate nanoscale materials with the biological recognition elements to assist in the rapid and sensitive detection of glucose. Here we present a highly sensitive and selective glucose sensor based on capacitor circuit that is capable...

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Autores principales:	Gymama Slaughter, Tanmay Kulkarni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e76c67065fea456698b9e80ff5285901
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spelling	oai:doaj.org-article:e76c67065fea456698b9e80ff52859012021-12-02T11:41:20ZHighly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit10.1038/s41598-017-01665-92045-2322https://doaj.org/article/e76c67065fea456698b9e80ff52859012017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01665-9https://doaj.org/toc/2045-2322Abstract Enzymatic glucose biosensors are being developed to incorporate nanoscale materials with the biological recognition elements to assist in the rapid and sensitive detection of glucose. Here we present a highly sensitive and selective glucose sensor based on capacitor circuit that is capable of selectively sensing glucose while simultaneously powering a small microelectronic device. Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucose dehydrogenase (PQQ-GDH) and bilirubin oxidase (BOD) at anode and cathode, respectively, in the biofuel cell arrangement. The input voltage (as low as 0.25 V) from the biofuel cell is converted to a stepped-up power and charged to the capacitor to the voltage of 1.8 V. The frequency of the charge/discharge cycle of the capacitor corresponded to the oxidation of glucose. The biofuel cell structure-based glucose sensor synergizes the advantages of both the glucose biosensor and biofuel cell. In addition, this glucose sensor favored a very high selectivity towards glucose in the presence of competing and non-competing analytes. It exhibited unprecedented sensitivity of 37.66 Hz/mM.cm2 and a linear range of 1 to 20 mM. This innovative self-powered glucose sensor opens new doors for implementation of biofuel cells and capacitor circuits for medical diagnosis and powering therapeutic devices.Gymama SlaughterTanmay KulkarniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gymama Slaughter Tanmay Kulkarni Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
description	Abstract Enzymatic glucose biosensors are being developed to incorporate nanoscale materials with the biological recognition elements to assist in the rapid and sensitive detection of glucose. Here we present a highly sensitive and selective glucose sensor based on capacitor circuit that is capable of selectively sensing glucose while simultaneously powering a small microelectronic device. Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucose dehydrogenase (PQQ-GDH) and bilirubin oxidase (BOD) at anode and cathode, respectively, in the biofuel cell arrangement. The input voltage (as low as 0.25 V) from the biofuel cell is converted to a stepped-up power and charged to the capacitor to the voltage of 1.8 V. The frequency of the charge/discharge cycle of the capacitor corresponded to the oxidation of glucose. The biofuel cell structure-based glucose sensor synergizes the advantages of both the glucose biosensor and biofuel cell. In addition, this glucose sensor favored a very high selectivity towards glucose in the presence of competing and non-competing analytes. It exhibited unprecedented sensitivity of 37.66 Hz/mM.cm2 and a linear range of 1 to 20 mM. This innovative self-powered glucose sensor opens new doors for implementation of biofuel cells and capacitor circuits for medical diagnosis and powering therapeutic devices.
format	article
author	Gymama Slaughter Tanmay Kulkarni
author_facet	Gymama Slaughter Tanmay Kulkarni
author_sort	Gymama Slaughter
title	Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
title_short	Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
title_full	Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
title_fullStr	Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
title_full_unstemmed	Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit
title_sort	highly selective and sensitive self-powered glucose sensor based on capacitor circuit
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e76c67065fea456698b9e80ff5285901
work_keys_str_mv	AT gymamaslaughter highlyselectiveandsensitiveselfpoweredglucosesensorbasedoncapacitorcircuit AT tanmaykulkarni highlyselectiveandsensitiveselfpoweredglucosesensorbasedoncapacitorcircuit
_version_	1718395433223454720

Highly Selective and Sensitive Self-Powered Glucose Sensor Based on Capacitor Circuit

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