Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.

<h4>Objective</h4>Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the associat...

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Autores principales:	Catherine Féart, Catherine Helmer, Hervé Fleury, Yannick Béjot, Karen Ritchie, Philippe Amouyel, Susanna Schraen-Maschke, Luc Buée, Jean-Charles Lambert, Luc Letenneur, Jean-François Dartigues
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e76c835c35224b4d8c631e42de6b8748
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spelling	oai:doaj.org-article:e76c835c35224b4d8c631e42de6b87482021-11-18T07:31:21ZAssociation between IgM anti-herpes simplex virus and plasma amyloid-beta levels.1932-620310.1371/journal.pone.0029480https://doaj.org/article/e76c835c35224b4d8c631e42de6b87482011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22216291/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels.<h4>Methods</h4>The study sample consisted of 1222 subjects (73.9 y in mean) from the Three-City cohort. IgM and IgG anti-HSV antibodies were quantified using an ELISA kit, and plasma levels of Aβ(1-40) and Aβ(1-42) were measured using an xMAP-based assay technology. Cross-sectional analyses of the associations between anti-HSV antibodies and plasma Aβ levels were performed by multi-linear regression.<h4>Results</h4>After adjustment for study center, age, sex, education, and apolipoprotein E-e4 polymorphism, plasma Aβ(1-42) and Aβ(1-40) levels were specifically inversely associated with anti-HSV IgM levels (β = -20.7, P=0.001 and β = -92.4, P=0.007, respectively). In a sub-sample with information on CLU- and CR1-linked SNPs genotyping (n=754), additional adjustment for CR1 or CLU markers did not modify these associations (adjustment for CR1 rs6656401, β = -25.6, P=0.002 for Aβ(1-42) and β = -132.7, P=0.002 for Aβ(1-40;) adjustment for CLU rs2279590, β = -25.6, P=0.002 for Aβ(1-42) and β = -134.8, P=0.002 for Aβ(1-40)). No association between the plasma Aβ(1-42)-to-Aβ(1-40) ratio and anti-HSV IgM or IgG were evidenced.<h4>Conclusion</h4>High anti-HSV IgM levels, markers of HSV reactivation, are associated with lower plasma Aβ(1-40) and Aβ(1-42) levels, which suggest a possible involvement of the virus in the alterations of the APP processing and potentially in the pathogenesis of AD in human.Catherine FéartCatherine HelmerHervé FleuryYannick BéjotKaren RitchiePhilippe AmouyelSusanna Schraen-MaschkeLuc BuéeJean-Charles LambertLuc LetenneurJean-François DartiguesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e29480 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine Féart Catherine Helmer Hervé Fleury Yannick Béjot Karen Ritchie Philippe Amouyel Susanna Schraen-Maschke Luc Buée Jean-Charles Lambert Luc Letenneur Jean-François Dartigues Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
description	<h4>Objective</h4>Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels.<h4>Methods</h4>The study sample consisted of 1222 subjects (73.9 y in mean) from the Three-City cohort. IgM and IgG anti-HSV antibodies were quantified using an ELISA kit, and plasma levels of Aβ(1-40) and Aβ(1-42) were measured using an xMAP-based assay technology. Cross-sectional analyses of the associations between anti-HSV antibodies and plasma Aβ levels were performed by multi-linear regression.<h4>Results</h4>After adjustment for study center, age, sex, education, and apolipoprotein E-e4 polymorphism, plasma Aβ(1-42) and Aβ(1-40) levels were specifically inversely associated with anti-HSV IgM levels (β = -20.7, P=0.001 and β = -92.4, P=0.007, respectively). In a sub-sample with information on CLU- and CR1-linked SNPs genotyping (n=754), additional adjustment for CR1 or CLU markers did not modify these associations (adjustment for CR1 rs6656401, β = -25.6, P=0.002 for Aβ(1-42) and β = -132.7, P=0.002 for Aβ(1-40;) adjustment for CLU rs2279590, β = -25.6, P=0.002 for Aβ(1-42) and β = -134.8, P=0.002 for Aβ(1-40)). No association between the plasma Aβ(1-42)-to-Aβ(1-40) ratio and anti-HSV IgM or IgG were evidenced.<h4>Conclusion</h4>High anti-HSV IgM levels, markers of HSV reactivation, are associated with lower plasma Aβ(1-40) and Aβ(1-42) levels, which suggest a possible involvement of the virus in the alterations of the APP processing and potentially in the pathogenesis of AD in human.
format	article
author	Catherine Féart Catherine Helmer Hervé Fleury Yannick Béjot Karen Ritchie Philippe Amouyel Susanna Schraen-Maschke Luc Buée Jean-Charles Lambert Luc Letenneur Jean-François Dartigues
author_facet	Catherine Féart Catherine Helmer Hervé Fleury Yannick Béjot Karen Ritchie Philippe Amouyel Susanna Schraen-Maschke Luc Buée Jean-Charles Lambert Luc Letenneur Jean-François Dartigues
author_sort	Catherine Féart
title	Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
title_short	Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
title_full	Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
title_fullStr	Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
title_full_unstemmed	Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
title_sort	association between igm anti-herpes simplex virus and plasma amyloid-beta levels.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e76c835c35224b4d8c631e42de6b8748
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Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.

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