Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis

Abstract The abundance and diversity of host-associated Prevotella species have a profound impact on human health. To investigate the composition, diversity, and functional roles of Prevotella in the human gut, a population-wide analysis was carried out on 586 healthy samples from western and non-we...

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Autores principales:	Vishnu Prasoodanan P. K., Ashok K. Sharma, Shruti Mahajan, Darshan B. Dhakan, Abhijit Maji, Joy Scaria, Vineet K. Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/e76cf7834a6c4e6884a3c7881287a116
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spelling	oai:doaj.org-article:e76cf7834a6c4e6884a3c7881287a1162021-12-02T18:37:13ZWestern and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis10.1038/s41522-021-00248-x2055-5008https://doaj.org/article/e76cf7834a6c4e6884a3c7881287a1162021-10-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00248-xhttps://doaj.org/toc/2055-5008Abstract The abundance and diversity of host-associated Prevotella species have a profound impact on human health. To investigate the composition, diversity, and functional roles of Prevotella in the human gut, a population-wide analysis was carried out on 586 healthy samples from western and non-western populations including the largest Indian cohort comprising of 200 samples, and 189 Inflammatory Bowel Disease samples from western populations. A higher abundance and diversity of Prevotella copri species enriched in complex plant polysaccharides metabolizing enzymes, particularly pullulanase containing polysaccharide-utilization-loci (PUL), were found in Indian and non-western populations. A higher diversity of oral inflammations-associated Prevotella species and an enrichment of virulence factors and antibiotic resistance genes in the gut microbiome of western populations speculates an existence of a mouth-gut axis. The study revealed the landscape of Prevotella composition in the human gut microbiome and its impact on health in western and non-western populations.Vishnu Prasoodanan P. K.Ashok K. SharmaShruti MahajanDarshan B. DhakanAbhijit MajiJoy ScariaVineet K. SharmaNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Vishnu Prasoodanan P. K. Ashok K. Sharma Shruti Mahajan Darshan B. Dhakan Abhijit Maji Joy Scaria Vineet K. Sharma Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
description	Abstract The abundance and diversity of host-associated Prevotella species have a profound impact on human health. To investigate the composition, diversity, and functional roles of Prevotella in the human gut, a population-wide analysis was carried out on 586 healthy samples from western and non-western populations including the largest Indian cohort comprising of 200 samples, and 189 Inflammatory Bowel Disease samples from western populations. A higher abundance and diversity of Prevotella copri species enriched in complex plant polysaccharides metabolizing enzymes, particularly pullulanase containing polysaccharide-utilization-loci (PUL), were found in Indian and non-western populations. A higher diversity of oral inflammations-associated Prevotella species and an enrichment of virulence factors and antibiotic resistance genes in the gut microbiome of western populations speculates an existence of a mouth-gut axis. The study revealed the landscape of Prevotella composition in the human gut microbiome and its impact on health in western and non-western populations.
format	article
author	Vishnu Prasoodanan P. K. Ashok K. Sharma Shruti Mahajan Darshan B. Dhakan Abhijit Maji Joy Scaria Vineet K. Sharma
author_facet	Vishnu Prasoodanan P. K. Ashok K. Sharma Shruti Mahajan Darshan B. Dhakan Abhijit Maji Joy Scaria Vineet K. Sharma
author_sort	Vishnu Prasoodanan P. K.
title	Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
title_short	Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
title_full	Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
title_fullStr	Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
title_full_unstemmed	Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis
title_sort	western and non-western gut microbiomes reveal new roles of prevotella in carbohydrate metabolism and mouth–gut axis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e76cf7834a6c4e6884a3c7881287a116
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Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth–gut axis

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