Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick

Abstract A micromachine constructed to possess various chemical and mechanical functions is one of the ultimate targets of technology. Conventional lithographic processes can be used to form complicated structures. However, they are basically limited to rigid and static structures with poor surface...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuki Sakamoto, Shoichi Toyabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e76ee447e5c44d85b01f95bd18e1f5c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e76ee447e5c44d85b01f95bd18e1f5c5
record_format	dspace
spelling	oai:doaj.org-article:e76ee447e5c44d85b01f95bd18e1f5c52021-12-02T16:06:32ZAssembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick10.1038/s41598-017-09804-y2045-2322https://doaj.org/article/e76ee447e5c44d85b01f95bd18e1f5c52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09804-yhttps://doaj.org/toc/2045-2322Abstract A micromachine constructed to possess various chemical and mechanical functions is one of the ultimate targets of technology. Conventional lithographic processes can be used to form complicated structures. However, they are basically limited to rigid and static structures with poor surface properties. Here, we demonstrate a novel method for assembling responsive and functional microstructures from diverse particles modified with DNA strands. The DNA strands are designed to form hairpins at room temperature and denature when heated. Structures are assembled through the simultaneous manipulation and heating of particles with “hot” optical tweezers, which incorporates the particles one by one. The flexible connection formed by DNA strands allows the responsive deformation of the structures with local controllability of the structural flexibility. We assembled a microscopic robot arm actuated by an external magnet, a hinge structure with a locally controlled connection flexibility and a three-dimensional double helix structure. The method is simple and can also be applied to build complex biological tissues from cells.Yuki SakamotoShoichi ToyabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuki Sakamoto Shoichi Toyabe Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
description	Abstract A micromachine constructed to possess various chemical and mechanical functions is one of the ultimate targets of technology. Conventional lithographic processes can be used to form complicated structures. However, they are basically limited to rigid and static structures with poor surface properties. Here, we demonstrate a novel method for assembling responsive and functional microstructures from diverse particles modified with DNA strands. The DNA strands are designed to form hairpins at room temperature and denature when heated. Structures are assembled through the simultaneous manipulation and heating of particles with “hot” optical tweezers, which incorporates the particles one by one. The flexible connection formed by DNA strands allows the responsive deformation of the structures with local controllability of the structural flexibility. We assembled a microscopic robot arm actuated by an external magnet, a hinge structure with a locally controlled connection flexibility and a three-dimensional double helix structure. The method is simple and can also be applied to build complex biological tissues from cells.
format	article
author	Yuki Sakamoto Shoichi Toyabe
author_facet	Yuki Sakamoto Shoichi Toyabe
author_sort	Yuki Sakamoto
title	Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
title_short	Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
title_full	Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
title_fullStr	Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
title_full_unstemmed	Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick
title_sort	assembly of a functional and responsive microstructure by heat bonding of dna-grafted colloidal brick
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e76ee447e5c44d85b01f95bd18e1f5c5
work_keys_str_mv	AT yukisakamoto assemblyofafunctionalandresponsivemicrostructurebyheatbondingofdnagraftedcolloidalbrick AT shoichitoyabe assemblyofafunctionalandresponsivemicrostructurebyheatbondingofdnagraftedcolloidalbrick
_version_	1718384997799297024

Assembly of a functional and responsive microstructure by heat bonding of DNA-grafted colloidal brick

Ejemplares similares