Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

Autophagy requires transport of autophagosomes to the perinuclear region. Here, the authors show that ORP1L localizes to autophagosomes and mediates formation of ER contact sites that prevent autophagosome transport and fusion with endocytic vesicles when cholesterol levels are low.

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Autores principales:	Ruud H. Wijdeven, Hans Janssen, Leila Nahidiazar, Lennert Janssen, Kees Jalink, Ilana Berlin, Jacques Neefjes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e77004c3d02c4a53a915513558bd9cb4
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spelling	oai:doaj.org-article:e77004c3d02c4a53a915513558bd9cb42021-12-02T17:31:19ZCholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway10.1038/ncomms118082041-1723https://doaj.org/article/e77004c3d02c4a53a915513558bd9cb42016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11808https://doaj.org/toc/2041-1723Autophagy requires transport of autophagosomes to the perinuclear region. Here, the authors show that ORP1L localizes to autophagosomes and mediates formation of ER contact sites that prevent autophagosome transport and fusion with endocytic vesicles when cholesterol levels are low.Ruud H. WijdevenHans JanssenLeila NahidiazarLennert JanssenKees JalinkIlana BerlinJacques NeefjesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruud H. Wijdeven Hans Janssen Leila Nahidiazar Lennert Janssen Kees Jalink Ilana Berlin Jacques Neefjes Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
description	Autophagy requires transport of autophagosomes to the perinuclear region. Here, the authors show that ORP1L localizes to autophagosomes and mediates formation of ER contact sites that prevent autophagosome transport and fusion with endocytic vesicles when cholesterol levels are low.
format	article
author	Ruud H. Wijdeven Hans Janssen Leila Nahidiazar Lennert Janssen Kees Jalink Ilana Berlin Jacques Neefjes
author_facet	Ruud H. Wijdeven Hans Janssen Leila Nahidiazar Lennert Janssen Kees Jalink Ilana Berlin Jacques Neefjes
author_sort	Ruud H. Wijdeven
title	Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
title_short	Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
title_full	Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
title_fullStr	Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
title_full_unstemmed	Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
title_sort	cholesterol and orp1l-mediated er contact sites control autophagosome transport and fusion with the endocytic pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e77004c3d02c4a53a915513558bd9cb4
work_keys_str_mv	AT ruudhwijdeven cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT hansjanssen cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT leilanahidiazar cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT lennertjanssen cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT keesjalink cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT ilanaberlin cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway AT jacquesneefjes cholesterolandorp1lmediatedercontactsitescontrolautophagosometransportandfusionwiththeendocyticpathway
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Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

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