Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention

Abstract Myocardial fibrosis and ventricular remodeling were the key pathology factors causing undesirable consequence after myocardial infarction. However, an efficient therapeutic method remains unclear, partly due to difficulty in continuously preventing neurohormonal overactivation and potential...

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Autores principales:	Zeping Qiu, Jingwen Zhao, Fanyi Huang, Luhan Bao, Yanjia Chen, Ke Yang, Wenguo Cui, Wei Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/e774ffa4f866423787236636797b8e4a
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spelling	oai:doaj.org-article:e774ffa4f866423787236636797b8e4a2021-12-02T16:27:51ZMyocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention10.1038/s41536-021-00154-y2057-3995https://doaj.org/article/e774ffa4f866423787236636797b8e4a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00154-yhttps://doaj.org/toc/2057-3995Abstract Myocardial fibrosis and ventricular remodeling were the key pathology factors causing undesirable consequence after myocardial infarction. However, an efficient therapeutic method remains unclear, partly due to difficulty in continuously preventing neurohormonal overactivation and potential disadvantages of cell therapy for clinical practice. In this study, a rhACE2-electrospun fibrous patch with sustained releasing of rhACE2 to shape an induction transformation niche in situ was introduced, through micro-sol electrospinning technologies. A durable releasing pattern of rhACE2 encapsulated in hyaluronic acid (HA)—poly(L-lactic acid) (PLLA) core-shell structure was observed. By multiple in vitro studies, the rhACE2 patch demonstrated effectiveness in reducing cardiomyocytes apoptosis under hypoxia stress and inhibiting cardiac fibroblasts proliferation, which gave evidence for its in vivo efficacy. For striking mice myocardial infarction experiments, a successful prevention of adverse ventricular remodeling has been demonstrated, reflecting by improved ejection fraction, normal ventricle structure and less fibrosis. The rhACE2 patch niche showed clear superiority in long term function and structure preservation after ischemia compared with intramyocardial injection. Thus, the micro-sol electrospun rhACE2 fibrous patch niche was proved to be efficient, cost-effective and easy-to-use in preventing ventricular adverse remodeling.Zeping QiuJingwen ZhaoFanyi HuangLuhan BaoYanjia ChenKe YangWenguo CuiWei JinNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Zeping Qiu Jingwen Zhao Fanyi Huang Luhan Bao Yanjia Chen Ke Yang Wenguo Cui Wei Jin Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
description	Abstract Myocardial fibrosis and ventricular remodeling were the key pathology factors causing undesirable consequence after myocardial infarction. However, an efficient therapeutic method remains unclear, partly due to difficulty in continuously preventing neurohormonal overactivation and potential disadvantages of cell therapy for clinical practice. In this study, a rhACE2-electrospun fibrous patch with sustained releasing of rhACE2 to shape an induction transformation niche in situ was introduced, through micro-sol electrospinning technologies. A durable releasing pattern of rhACE2 encapsulated in hyaluronic acid (HA)—poly(L-lactic acid) (PLLA) core-shell structure was observed. By multiple in vitro studies, the rhACE2 patch demonstrated effectiveness in reducing cardiomyocytes apoptosis under hypoxia stress and inhibiting cardiac fibroblasts proliferation, which gave evidence for its in vivo efficacy. For striking mice myocardial infarction experiments, a successful prevention of adverse ventricular remodeling has been demonstrated, reflecting by improved ejection fraction, normal ventricle structure and less fibrosis. The rhACE2 patch niche showed clear superiority in long term function and structure preservation after ischemia compared with intramyocardial injection. Thus, the micro-sol electrospun rhACE2 fibrous patch niche was proved to be efficient, cost-effective and easy-to-use in preventing ventricular adverse remodeling.
format	article
author	Zeping Qiu Jingwen Zhao Fanyi Huang Luhan Bao Yanjia Chen Ke Yang Wenguo Cui Wei Jin
author_facet	Zeping Qiu Jingwen Zhao Fanyi Huang Luhan Bao Yanjia Chen Ke Yang Wenguo Cui Wei Jin
author_sort	Zeping Qiu
title	Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
title_short	Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
title_full	Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
title_fullStr	Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
title_full_unstemmed	Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention
title_sort	myocardial fibrosis reversion via rhace2-electrospun fibrous patch for ventricular remodeling prevention
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e774ffa4f866423787236636797b8e4a
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Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention

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