Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers

Abstract The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step proces...

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Autores principales:	Myung-Hee Song, Thi Phuong Thuy Pham, Yeoung-Sang Yun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e776056222ab4610a6751e64df4e65b8
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spelling	oai:doaj.org-article:e776056222ab4610a6751e64df4e65b82021-12-02T16:45:46ZIonic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers10.1038/s41598-020-70900-72045-2322https://doaj.org/article/e776056222ab4610a6751e64df4e65b82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70900-7https://doaj.org/toc/2045-2322Abstract The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step process. Water molecules present in the CS beads diffused outward upon contact with the cellulose–IL mixture and acted as an anti-solvent. This allowed the surface of the beads to be coated with the regenerated cellulose. The regenerated cellulose was characterized by FE-SEM, FT-IR, and XRD analyses. To test potential application of the cellulose-coated CS hydrogel beads as a drug carrier, verapamil hydrochloride (VRP), used as a model drug, was impregnated into the beads. When the VRP-impregnated beads were immersed in the simulated gastric fluid (pH 1.2), the VRP was released in an almost ideal linear pattern. This easily fabricated cellulose-coated CS beads showed the possibility for application as carriers for drug release control.Myung-Hee SongThi Phuong Thuy PhamYeoung-Sang YunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myung-Hee Song Thi Phuong Thuy Pham Yeoung-Sang Yun Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
description	Abstract The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step process. Water molecules present in the CS beads diffused outward upon contact with the cellulose–IL mixture and acted as an anti-solvent. This allowed the surface of the beads to be coated with the regenerated cellulose. The regenerated cellulose was characterized by FE-SEM, FT-IR, and XRD analyses. To test potential application of the cellulose-coated CS hydrogel beads as a drug carrier, verapamil hydrochloride (VRP), used as a model drug, was impregnated into the beads. When the VRP-impregnated beads were immersed in the simulated gastric fluid (pH 1.2), the VRP was released in an almost ideal linear pattern. This easily fabricated cellulose-coated CS beads showed the possibility for application as carriers for drug release control.
format	article
author	Myung-Hee Song Thi Phuong Thuy Pham Yeoung-Sang Yun
author_facet	Myung-Hee Song Thi Phuong Thuy Pham Yeoung-Sang Yun
author_sort	Myung-Hee Song
title	Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
title_short	Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
title_full	Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
title_fullStr	Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
title_full_unstemmed	Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
title_sort	ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e776056222ab4610a6751e64df4e65b8
work_keys_str_mv	AT myungheesong ionicliquidassistedcellulosecoatingofchitosanhydrogelbeadsandtheirapplicationasdrugcarriers AT thiphuongthuypham ionicliquidassistedcellulosecoatingofchitosanhydrogelbeadsandtheirapplicationasdrugcarriers AT yeoungsangyun ionicliquidassistedcellulosecoatingofchitosanhydrogelbeadsandtheirapplicationasdrugcarriers
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Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers

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