Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.

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Detalles Bibliográficos
Autores principales: Xionghui Ding, Hiroto Kambara, Rongxia Guo, Apurva Kanneganti, Maikel Acosta-Zaldívar, Jiajia Li, Fei Liu, Ting Bei, Wanjun Qi, Xuemei Xie, Wenli Han, Ningning Liu, Cunling Zhang, Xiaoyu Zhang, Hongbo Yu, Li Zhao, Fengxia Ma, Julia R. Köhler, Hongbo R. Luo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/e7787a117ee6429d98db5af480b18015
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Sumario:Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.

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