Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.

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Autores principales: Xionghui Ding, Hiroto Kambara, Rongxia Guo, Apurva Kanneganti, Maikel Acosta-Zaldívar, Jiajia Li, Fei Liu, Ting Bei, Wanjun Qi, Xuemei Xie, Wenli Han, Ningning Liu, Cunling Zhang, Xiaoyu Zhang, Hongbo Yu, Li Zhao, Fengxia Ma, Julia R. Köhler, Hongbo R. Luo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e7787a117ee6429d98db5af480b18015
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spelling oai:doaj.org-article:e7787a117ee6429d98db5af480b180152021-11-21T12:35:19ZInflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages10.1038/s41467-021-27034-92041-1723https://doaj.org/article/e7787a117ee6429d98db5af480b180152021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27034-9https://doaj.org/toc/2041-1723Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.Xionghui DingHiroto KambaraRongxia GuoApurva KannegantiMaikel Acosta-ZaldívarJiajia LiFei LiuTing BeiWanjun QiXuemei XieWenli HanNingning LiuCunling ZhangXiaoyu ZhangHongbo YuLi ZhaoFengxia MaJulia R. KöhlerHongbo R. LuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xionghui Ding
Hiroto Kambara
Rongxia Guo
Apurva Kanneganti
Maikel Acosta-Zaldívar
Jiajia Li
Fei Liu
Ting Bei
Wanjun Qi
Xuemei Xie
Wenli Han
Ningning Liu
Cunling Zhang
Xiaoyu Zhang
Hongbo Yu
Li Zhao
Fengxia Ma
Julia R. Köhler
Hongbo R. Luo
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
description Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.
format article
author Xionghui Ding
Hiroto Kambara
Rongxia Guo
Apurva Kanneganti
Maikel Acosta-Zaldívar
Jiajia Li
Fei Liu
Ting Bei
Wanjun Qi
Xuemei Xie
Wenli Han
Ningning Liu
Cunling Zhang
Xiaoyu Zhang
Hongbo Yu
Li Zhao
Fengxia Ma
Julia R. Köhler
Hongbo R. Luo
author_facet Xionghui Ding
Hiroto Kambara
Rongxia Guo
Apurva Kanneganti
Maikel Acosta-Zaldívar
Jiajia Li
Fei Liu
Ting Bei
Wanjun Qi
Xuemei Xie
Wenli Han
Ningning Liu
Cunling Zhang
Xiaoyu Zhang
Hongbo Yu
Li Zhao
Fengxia Ma
Julia R. Köhler
Hongbo R. Luo
author_sort Xionghui Ding
title Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
title_short Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
title_full Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
title_fullStr Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
title_full_unstemmed Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
title_sort inflammasome-mediated gsdmd activation facilitates escape of candida albicans from macrophages
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e7787a117ee6429d98db5af480b18015
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