Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis

Lysine hydroxylation of procollagen precursors by LH3 is required for collagen fibril crosslinking and stabilization. Here the authors show that the trafficking protein VIPAR is required for correct sorting of LH3 into post-Golgi collagen carriers and for correct collagen modification and structure.

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Autores principales:	Blerida Banushi, Federico Forneris, Anna Straatman-Iwanowska, Adam Strange, Anne-Marie Lyne, Clare Rogerson, Jemima J. Burden, Wendy E. Heywood, Joanna Hanley, Ivan Doykov, Kornelis R. Straatman, Holly Smith, Danai Bem, Janos Kriston-Vizi, Gema Ariceta, Maija Risteli, Chunguang Wang, Rosalyn E. Ardill, Marcin Zaniew, Julita Latka-Grot, Simon N. Waddington, S. J. Howe, Francesco Ferraro, Asllan Gjinovci, Scott Lawrence, Mark Marsh, Mark Girolami, Laurent Bozec, Kevin Mills, Paul Gissen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e77a5c9ad1f34f37a39287201a081ba7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e77a5c9ad1f34f37a39287201a081ba72021-12-02T14:39:49ZRegulation of post-Golgi LH3 trafficking is essential for collagen homeostasis10.1038/ncomms121112041-1723https://doaj.org/article/e77a5c9ad1f34f37a39287201a081ba72016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12111https://doaj.org/toc/2041-1723Lysine hydroxylation of procollagen precursors by LH3 is required for collagen fibril crosslinking and stabilization. Here the authors show that the trafficking protein VIPAR is required for correct sorting of LH3 into post-Golgi collagen carriers and for correct collagen modification and structure.Blerida BanushiFederico FornerisAnna Straatman-IwanowskaAdam StrangeAnne-Marie LyneClare RogersonJemima J. BurdenWendy E. HeywoodJoanna HanleyIvan DoykovKornelis R. StraatmanHolly SmithDanai BemJanos Kriston-ViziGema AricetaMaija RisteliChunguang WangRosalyn E. ArdillMarcin ZaniewJulita Latka-GrotSimon N. WaddingtonS. J. HoweFrancesco FerraroAsllan GjinovciScott LawrenceMark MarshMark GirolamiLaurent BozecKevin MillsPaul GissenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Blerida Banushi Federico Forneris Anna Straatman-Iwanowska Adam Strange Anne-Marie Lyne Clare Rogerson Jemima J. Burden Wendy E. Heywood Joanna Hanley Ivan Doykov Kornelis R. Straatman Holly Smith Danai Bem Janos Kriston-Vizi Gema Ariceta Maija Risteli Chunguang Wang Rosalyn E. Ardill Marcin Zaniew Julita Latka-Grot Simon N. Waddington S. J. Howe Francesco Ferraro Asllan Gjinovci Scott Lawrence Mark Marsh Mark Girolami Laurent Bozec Kevin Mills Paul Gissen Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
description	Lysine hydroxylation of procollagen precursors by LH3 is required for collagen fibril crosslinking and stabilization. Here the authors show that the trafficking protein VIPAR is required for correct sorting of LH3 into post-Golgi collagen carriers and for correct collagen modification and structure.
format	article
author	Blerida Banushi Federico Forneris Anna Straatman-Iwanowska Adam Strange Anne-Marie Lyne Clare Rogerson Jemima J. Burden Wendy E. Heywood Joanna Hanley Ivan Doykov Kornelis R. Straatman Holly Smith Danai Bem Janos Kriston-Vizi Gema Ariceta Maija Risteli Chunguang Wang Rosalyn E. Ardill Marcin Zaniew Julita Latka-Grot Simon N. Waddington S. J. Howe Francesco Ferraro Asllan Gjinovci Scott Lawrence Mark Marsh Mark Girolami Laurent Bozec Kevin Mills Paul Gissen
author_facet	Blerida Banushi Federico Forneris Anna Straatman-Iwanowska Adam Strange Anne-Marie Lyne Clare Rogerson Jemima J. Burden Wendy E. Heywood Joanna Hanley Ivan Doykov Kornelis R. Straatman Holly Smith Danai Bem Janos Kriston-Vizi Gema Ariceta Maija Risteli Chunguang Wang Rosalyn E. Ardill Marcin Zaniew Julita Latka-Grot Simon N. Waddington S. J. Howe Francesco Ferraro Asllan Gjinovci Scott Lawrence Mark Marsh Mark Girolami Laurent Bozec Kevin Mills Paul Gissen
author_sort	Blerida Banushi
title	Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
title_short	Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
title_full	Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
title_fullStr	Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
title_full_unstemmed	Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
title_sort	regulation of post-golgi lh3 trafficking is essential for collagen homeostasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e77a5c9ad1f34f37a39287201a081ba7
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Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis

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