Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease

Yuerui Li, Juan Wang, Lyu Lv, Cui Xu, Hongbin Liu Department of Geriatric Cardiology, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China Objective: The current risk model for long-term prediction in coronary artery disease (CAD) is complicated, w...

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Autores principales:	Li Y, Wang J, Lv L, Xu C, Liu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	CHADS2 score R2CHADS2 score coronary artery disease prognosis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e77ad4656e254f77837af5a16b35ea6d
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spelling	oai:doaj.org-article:e77ad4656e254f77837af5a16b35ea6d2021-12-02T06:36:02ZUsefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease1178-1998https://doaj.org/article/e77ad4656e254f77837af5a16b35ea6d2018-04-01T00:00:00Zhttps://www.dovepress.com/usefulness-of-the-chads2-and-r2chads2-scores-for-prognostic-stratifica-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yuerui Li, Juan Wang, Lyu Lv, Cui Xu, Hongbin Liu Department of Geriatric Cardiology, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China Objective: The current risk model for long-term prediction in coronary artery disease (CAD) is complicated, while a simple useful model is still lacking. We aim to investigate if CHADS2 and R2CHADS2 scores could predict long-term outcome for patients with CAD. Patients and methods: We enrolled 3,700 patients with CAD between November 2010 and September 2014 at the Department of Cardiology from Chinese PLA General Hospital. The CHADS2 and R2CHADS2 scores were calculated. All cases were followed to track the incidence of composite end point consisting of cardiovascular (CV) death, myocardial infarction (MI), stroke, heart failure, and all-cause death. Results: During a median 2.9-year follow-up, 443 patients experienced at least one element of the composite end point of CV death (n=168 [4.6%]), MI (n=59 [1.6%]), stroke (n=96 [2.6%]), heart failure (n=101 [2.8%]), and all-cause death (n=240 [6.6%]). Multivariate Cox regression analyses showed that the CHADS2 score (hazard ratio [HR]: 2.18, 95% CI: 2.00–2.38, p<0.0001) and the R2CHADS2 score (HR: 1.93, 95% CI: 1.83–2.04, p<0.0001) were independently associated with composite outcome. Receiver-operating characteristic analysis showed that compared with the CHADS2 score, the R2CHADS2 score had better discrimination for the prediction of long-term combined outcome (0.772 vs 0.791, p=0.0013). Conclusion: CHADS2 and R2CHADS2 scores provide a quick and useful tool in predicting long-term outcome for patients with CAD. Keywords: CHADS2 score, R2CHADS2 score, coronary artery disease, prognosis, risk factors, renal functionLi YWang JLv LXu CLiu HDove Medical PressarticleCHADS2 scoreR2CHADS2 scorecoronary artery diseaseprognosisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 565-571 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	CHADS2 score R2CHADS2 score coronary artery disease prognosis Geriatrics RC952-954.6
spellingShingle	CHADS2 score R2CHADS2 score coronary artery disease prognosis Geriatrics RC952-954.6 Li Y Wang J Lv L Xu C Liu H Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
description	Yuerui Li, Juan Wang, Lyu Lv, Cui Xu, Hongbin Liu Department of Geriatric Cardiology, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China Objective: The current risk model for long-term prediction in coronary artery disease (CAD) is complicated, while a simple useful model is still lacking. We aim to investigate if CHADS2 and R2CHADS2 scores could predict long-term outcome for patients with CAD. Patients and methods: We enrolled 3,700 patients with CAD between November 2010 and September 2014 at the Department of Cardiology from Chinese PLA General Hospital. The CHADS2 and R2CHADS2 scores were calculated. All cases were followed to track the incidence of composite end point consisting of cardiovascular (CV) death, myocardial infarction (MI), stroke, heart failure, and all-cause death. Results: During a median 2.9-year follow-up, 443 patients experienced at least one element of the composite end point of CV death (n=168 [4.6%]), MI (n=59 [1.6%]), stroke (n=96 [2.6%]), heart failure (n=101 [2.8%]), and all-cause death (n=240 [6.6%]). Multivariate Cox regression analyses showed that the CHADS2 score (hazard ratio [HR]: 2.18, 95% CI: 2.00–2.38, p<0.0001) and the R2CHADS2 score (HR: 1.93, 95% CI: 1.83–2.04, p<0.0001) were independently associated with composite outcome. Receiver-operating characteristic analysis showed that compared with the CHADS2 score, the R2CHADS2 score had better discrimination for the prediction of long-term combined outcome (0.772 vs 0.791, p=0.0013). Conclusion: CHADS2 and R2CHADS2 scores provide a quick and useful tool in predicting long-term outcome for patients with CAD. Keywords: CHADS2 score, R2CHADS2 score, coronary artery disease, prognosis, risk factors, renal function
format	article
author	Li Y Wang J Lv L Xu C Liu H
author_facet	Li Y Wang J Lv L Xu C Liu H
author_sort	Li Y
title	Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
title_short	Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
title_full	Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
title_fullStr	Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
title_full_unstemmed	Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease
title_sort	usefulness of the chads2 and r2chads2 scores for prognostic stratification in patients with coronary artery disease
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e77ad4656e254f77837af5a16b35ea6d
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_version_	1718399844954931200

Usefulness of the CHADS2 and R2CHADS2 scores for prognostic stratification in patients with coronary artery disease

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