Pharmacognostic evaluation of leaves of Dysoxylum binectariferum

Background: Dysoxylum binectariferum is widely known for its medicinal properties. The leaves of this plant are major source of rohitukine, a precursor of the anti-cancer compound flavopiridol. Purpose: To provide standardization parameters for leaves of Dysoxylum binectariferum for identification o...

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Autores principales:	Rajesh Ankalge, Mangesh Jagdale, Sonali Ghaytidak, Kalpesh Patil, Lata Manani, Sonal Desai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Dysoxylum binectariferum Lassuni amari Meliaceae Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/e77f5aa942534981a9672d8b7aad83e5
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spelling	oai:doaj.org-article:e77f5aa942534981a9672d8b7aad83e52021-11-06T04:42:28ZPharmacognostic evaluation of leaves of Dysoxylum binectariferum2667-031310.1016/j.phyplu.2021.100149https://doaj.org/article/e77f5aa942534981a9672d8b7aad83e52021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001317https://doaj.org/toc/2667-0313Background: Dysoxylum binectariferum is widely known for its medicinal properties. The leaves of this plant are major source of rohitukine, a precursor of the anti-cancer compound flavopiridol. Purpose: To provide standardization parameters for leaves of Dysoxylum binectariferum for identification of correct plant material and for preparation of monograph. Methods: Macroscopic evaluation, microscopic evaluation and powder characteristics of leaves of D. binectariferum were carried out. Physico-chemical parameters of leaves were also evaluated. Preliminary phytochemical analysis was carried out using various chemical tests. HPTLC fingerprints were obtained using Silica gel 60 F254 plates as stationary phase and toluene: ethyl acetate: formic acid (5:1.5: 0.5, v/v/v) as mobile phase. Heavy metals were evaluated by inductively coupled plasma-optical emission spectroscopy. Pesticides were determined by gas chromatography-mass spectroscopy. Aflatoxins were evaluated using HPTLC studies. Results: Macroscopy, microscopy and powder characteristics revealed presence of well-defined cellular structures. The ethanol soluble extractive and water-soluble extractive values were 11.2 ± 0.11 and 20.8 ± 0.23, respectively. The total ash, acid insoluble ash and water-soluble ash were found to be 10.73±0.95% w/w, 0.74±0.48% w/w and 3.35±1.07% w/w, respectively. The moisture content was found to be 19.0 ± 0.60% w/w. Extractive values of samples in different solvents such as methanol, ethanol, water, ethyl acetate, petroleum ether and chloroform were determined. Preliminary phytochemical screening of these extracts revealed the presence of steroids, tannins, flavonoids, alkaloids, glycosides and carbohydrates. The heavy metals were found to be in permissible limits. The plant material under study was free from pesticides and aflatoxins. Conclusion: The parameters studied above can be useful for identification and authentication of plant material of D. binectariferum.Rajesh AnkalgeMangesh JagdaleSonali GhaytidakKalpesh PatilLata MananiSonal DesaiElsevierarticleDysoxylum binectariferumLassuni amariMeliaceaeOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 1, Iss 4, Pp 100149- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dysoxylum binectariferum Lassuni amari Meliaceae Other systems of medicine RZ201-999
spellingShingle	Dysoxylum binectariferum Lassuni amari Meliaceae Other systems of medicine RZ201-999 Rajesh Ankalge Mangesh Jagdale Sonali Ghaytidak Kalpesh Patil Lata Manani Sonal Desai Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
description	Background: Dysoxylum binectariferum is widely known for its medicinal properties. The leaves of this plant are major source of rohitukine, a precursor of the anti-cancer compound flavopiridol. Purpose: To provide standardization parameters for leaves of Dysoxylum binectariferum for identification of correct plant material and for preparation of monograph. Methods: Macroscopic evaluation, microscopic evaluation and powder characteristics of leaves of D. binectariferum were carried out. Physico-chemical parameters of leaves were also evaluated. Preliminary phytochemical analysis was carried out using various chemical tests. HPTLC fingerprints were obtained using Silica gel 60 F254 plates as stationary phase and toluene: ethyl acetate: formic acid (5:1.5: 0.5, v/v/v) as mobile phase. Heavy metals were evaluated by inductively coupled plasma-optical emission spectroscopy. Pesticides were determined by gas chromatography-mass spectroscopy. Aflatoxins were evaluated using HPTLC studies. Results: Macroscopy, microscopy and powder characteristics revealed presence of well-defined cellular structures. The ethanol soluble extractive and water-soluble extractive values were 11.2 ± 0.11 and 20.8 ± 0.23, respectively. The total ash, acid insoluble ash and water-soluble ash were found to be 10.73±0.95% w/w, 0.74±0.48% w/w and 3.35±1.07% w/w, respectively. The moisture content was found to be 19.0 ± 0.60% w/w. Extractive values of samples in different solvents such as methanol, ethanol, water, ethyl acetate, petroleum ether and chloroform were determined. Preliminary phytochemical screening of these extracts revealed the presence of steroids, tannins, flavonoids, alkaloids, glycosides and carbohydrates. The heavy metals were found to be in permissible limits. The plant material under study was free from pesticides and aflatoxins. Conclusion: The parameters studied above can be useful for identification and authentication of plant material of D. binectariferum.
format	article
author	Rajesh Ankalge Mangesh Jagdale Sonali Ghaytidak Kalpesh Patil Lata Manani Sonal Desai
author_facet	Rajesh Ankalge Mangesh Jagdale Sonali Ghaytidak Kalpesh Patil Lata Manani Sonal Desai
author_sort	Rajesh Ankalge
title	Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
title_short	Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
title_full	Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
title_fullStr	Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
title_full_unstemmed	Pharmacognostic evaluation of leaves of Dysoxylum binectariferum
title_sort	pharmacognostic evaluation of leaves of dysoxylum binectariferum
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e77f5aa942534981a9672d8b7aad83e5
work_keys_str_mv	AT rajeshankalge pharmacognosticevaluationofleavesofdysoxylumbinectariferum AT mangeshjagdale pharmacognosticevaluationofleavesofdysoxylumbinectariferum AT sonalighaytidak pharmacognosticevaluationofleavesofdysoxylumbinectariferum AT kalpeshpatil pharmacognosticevaluationofleavesofdysoxylumbinectariferum AT latamanani pharmacognosticevaluationofleavesofdysoxylumbinectariferum AT sonaldesai pharmacognosticevaluationofleavesofdysoxylumbinectariferum
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Pharmacognostic evaluation of leaves of Dysoxylum binectariferum

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