Chirality imprinting and direct asymmetric reaction screening using a stereodynamic Brønsted/Lewis acid receptor

Determining results of asymmetric reactions can take long periods of time and consume large amounts of organic solvents during work-up and analysis. Here, the authors report a bifunctional organic probe that can bind to chiral hydroxyacids, and provide yield, enantiomeric excess and absolute configu...

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Autores principales: Keith W. Bentley, Daysi Proano, Christian Wolf
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e77f8baa04984dda8c81a509c2b86eab
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Sumario:Determining results of asymmetric reactions can take long periods of time and consume large amounts of organic solvents during work-up and analysis. Here, the authors report a bifunctional organic probe that can bind to chiral hydroxyacids, and provide yield, enantiomeric excess and absolute configuration even with crude mixtures.