Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives

Abstract Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrol...

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Autores principales:	Daniel T. Payne, Yiming Zhao, John S. Fossey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e781f5bbc6db4ab482e5debc192d852e
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spelling	oai:doaj.org-article:e781f5bbc6db4ab482e5debc192d852e2021-12-02T16:08:08ZEthylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives10.1038/s41598-017-01950-72045-2322https://doaj.org/article/e781f5bbc6db4ab482e5debc192d852e2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01950-7https://doaj.org/toc/2045-2322Abstract Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.Daniel T. PayneYiming ZhaoJohn S. FosseyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel T. Payne Yiming Zhao John S. Fossey Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
description	Abstract Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.
format	article
author	Daniel T. Payne Yiming Zhao John S. Fossey
author_facet	Daniel T. Payne Yiming Zhao John S. Fossey
author_sort	Daniel T. Payne
title	Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
title_short	Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
title_full	Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
title_fullStr	Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
title_full_unstemmed	Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
title_sort	ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e781f5bbc6db4ab482e5debc192d852e
work_keys_str_mv	AT danieltpayne ethylenationofaldehydesto3propanalpropanolandpropanoicacidderivatives AT yimingzhao ethylenationofaldehydesto3propanalpropanolandpropanoicacidderivatives AT johnsfossey ethylenationofaldehydesto3propanalpropanolandpropanoicacidderivatives
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Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives

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