Structural basis of TFIIH activation for nucleotide excision repair

The NER machinery contains the multisubunit transcription factor IIH (TFIIH) that opens the DNA repair bubble, scans for the lesion, and coordinates excision of the damaged site. Here the authors resolve the cryo-electron microscopy structure of the human core TFIIH-XPA-DNA complex and provide insig...

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Autores principales:	Goran Kokic, Aleksandar Chernev, Dimitry Tegunov, Christian Dienemann, Henning Urlaub, Patrick Cramer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e78879352b5b40f5876dc4552e176e0a
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spelling	oai:doaj.org-article:e78879352b5b40f5876dc4552e176e0a2021-12-02T16:58:29ZStructural basis of TFIIH activation for nucleotide excision repair10.1038/s41467-019-10745-52041-1723https://doaj.org/article/e78879352b5b40f5876dc4552e176e0a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10745-5https://doaj.org/toc/2041-1723The NER machinery contains the multisubunit transcription factor IIH (TFIIH) that opens the DNA repair bubble, scans for the lesion, and coordinates excision of the damaged site. Here the authors resolve the cryo-electron microscopy structure of the human core TFIIH-XPA-DNA complex and provide insights into its activation.Goran KokicAleksandar ChernevDimitry TegunovChristian DienemannHenning UrlaubPatrick CramerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Goran Kokic Aleksandar Chernev Dimitry Tegunov Christian Dienemann Henning Urlaub Patrick Cramer Structural basis of TFIIH activation for nucleotide excision repair
description	The NER machinery contains the multisubunit transcription factor IIH (TFIIH) that opens the DNA repair bubble, scans for the lesion, and coordinates excision of the damaged site. Here the authors resolve the cryo-electron microscopy structure of the human core TFIIH-XPA-DNA complex and provide insights into its activation.
format	article
author	Goran Kokic Aleksandar Chernev Dimitry Tegunov Christian Dienemann Henning Urlaub Patrick Cramer
author_facet	Goran Kokic Aleksandar Chernev Dimitry Tegunov Christian Dienemann Henning Urlaub Patrick Cramer
author_sort	Goran Kokic
title	Structural basis of TFIIH activation for nucleotide excision repair
title_short	Structural basis of TFIIH activation for nucleotide excision repair
title_full	Structural basis of TFIIH activation for nucleotide excision repair
title_fullStr	Structural basis of TFIIH activation for nucleotide excision repair
title_full_unstemmed	Structural basis of TFIIH activation for nucleotide excision repair
title_sort	structural basis of tfiih activation for nucleotide excision repair
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e78879352b5b40f5876dc4552e176e0a
work_keys_str_mv	AT gorankokic structuralbasisoftfiihactivationfornucleotideexcisionrepair AT aleksandarchernev structuralbasisoftfiihactivationfornucleotideexcisionrepair AT dimitrytegunov structuralbasisoftfiihactivationfornucleotideexcisionrepair AT christiandienemann structuralbasisoftfiihactivationfornucleotideexcisionrepair AT henningurlaub structuralbasisoftfiihactivationfornucleotideexcisionrepair AT patrickcramer structuralbasisoftfiihactivationfornucleotideexcisionrepair
_version_	1718382301093560320

Structural basis of TFIIH activation for nucleotide excision repair

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