Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation machinery to adherens junctions.

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Autores principales:	Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e78b4bf4b2f348dc937c00673a6a639b
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spelling	oai:doaj.org-article:e78b4bf4b2f348dc937c00673a6a639b2021-12-02T17:31:51ZNeogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension10.1038/ncomms110822041-1723https://doaj.org/article/e78b4bf4b2f348dc937c00673a6a639b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11082https://doaj.org/toc/2041-1723The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation machinery to adherens junctions.Natalie K. LeeKa Wai FokAmanda WhiteNicole H. WilsonConor J. O’LearyHayley L. CoxMagdalene MichaelAlpha S. YapHelen M. CooperNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalie K. Lee Ka Wai Fok Amanda White Nicole H. Wilson Conor J. O’Leary Hayley L. Cox Magdalene Michael Alpha S. Yap Helen M. Cooper Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
description	The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation machinery to adherens junctions.
format	article
author	Natalie K. Lee Ka Wai Fok Amanda White Nicole H. Wilson Conor J. O’Leary Hayley L. Cox Magdalene Michael Alpha S. Yap Helen M. Cooper
author_facet	Natalie K. Lee Ka Wai Fok Amanda White Nicole H. Wilson Conor J. O’Leary Hayley L. Cox Magdalene Michael Alpha S. Yap Helen M. Cooper
author_sort	Natalie K. Lee
title	Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
title_short	Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
title_full	Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
title_fullStr	Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
title_full_unstemmed	Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
title_sort	neogenin recruitment of the wave regulatory complex maintains adherens junction stability and tension
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e78b4bf4b2f348dc937c00673a6a639b
work_keys_str_mv	AT natalieklee neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT kawaifok neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT amandawhite neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT nicolehwilson neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT conorjoleary neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT hayleylcox neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT magdalenemichael neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT alphasyap neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension AT helenmcooper neogeninrecruitmentofthewaveregulatorycomplexmaintainsadherensjunctionstabilityandtension
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Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

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