Choroidal structural evaluation in celiac disease

Abstract This observational case–control study assessed the differences in choroidal structure between patients with celiac disease and healthy subjects utilizing the choroidal vascularity index (CVI). Seventy-four celiac patients and 67 healthy subjects underwent a complete ophthalmological evaluat...

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Autores principales:	Maddalena De Bernardo, Livio Vitiello, Michela Battipaglia, Francesca Mascolo, Claudio Iovino, Luigi Capasso, Carolina Ciacci, Nicola Rosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e78b556386fd4d7ca7e78a8582d5ea0d
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spelling	oai:doaj.org-article:e78b556386fd4d7ca7e78a8582d5ea0d2021-12-02T18:51:01ZChoroidal structural evaluation in celiac disease10.1038/s41598-021-95812-y2045-2322https://doaj.org/article/e78b556386fd4d7ca7e78a8582d5ea0d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95812-yhttps://doaj.org/toc/2045-2322Abstract This observational case–control study assessed the differences in choroidal structure between patients with celiac disease and healthy subjects utilizing the choroidal vascularity index (CVI). Seventy-four celiac patients and 67 healthy subjects underwent a complete ophthalmological evaluation, axial length (AL) measurements and spectral-domain optical coherence tomography with enhanced depth imaging mode (EDI SD-OCT) evaluation. These images were binarized and choroidal vasculature was analyzed. Choroidal total subfoveal area (TSA), luminal subfoveal area (LSA), stromal subfoveal area (SSA), CVI and subfoveal choroidal thickness (CT) were measured. Furthermore, subfoveal CT, TSA, LSA, SSA, and CVI were also correlated with AL. A statistically significant difference was found between the two groups for TSA, LSA, SSA and subfoveal CT, but not for CVI. In celiac patients, a significant correlation was found between AL and TSA, LSA and SSA, but not with CVI. Similar findings were also noticed in the healthy subjects. Thus, celiac patients have a thicker choroid than healthy subjects, regardless of the AL, due to a proportional increase in both the vascular and stromal components, which does not alter the CVI.Maddalena De BernardoLivio VitielloMichela BattipagliaFrancesca MascoloClaudio IovinoLuigi CapassoCarolina CiacciNicola RosaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maddalena De Bernardo Livio Vitiello Michela Battipaglia Francesca Mascolo Claudio Iovino Luigi Capasso Carolina Ciacci Nicola Rosa Choroidal structural evaluation in celiac disease
description	Abstract This observational case–control study assessed the differences in choroidal structure between patients with celiac disease and healthy subjects utilizing the choroidal vascularity index (CVI). Seventy-four celiac patients and 67 healthy subjects underwent a complete ophthalmological evaluation, axial length (AL) measurements and spectral-domain optical coherence tomography with enhanced depth imaging mode (EDI SD-OCT) evaluation. These images were binarized and choroidal vasculature was analyzed. Choroidal total subfoveal area (TSA), luminal subfoveal area (LSA), stromal subfoveal area (SSA), CVI and subfoveal choroidal thickness (CT) were measured. Furthermore, subfoveal CT, TSA, LSA, SSA, and CVI were also correlated with AL. A statistically significant difference was found between the two groups for TSA, LSA, SSA and subfoveal CT, but not for CVI. In celiac patients, a significant correlation was found between AL and TSA, LSA and SSA, but not with CVI. Similar findings were also noticed in the healthy subjects. Thus, celiac patients have a thicker choroid than healthy subjects, regardless of the AL, due to a proportional increase in both the vascular and stromal components, which does not alter the CVI.
format	article
author	Maddalena De Bernardo Livio Vitiello Michela Battipaglia Francesca Mascolo Claudio Iovino Luigi Capasso Carolina Ciacci Nicola Rosa
author_facet	Maddalena De Bernardo Livio Vitiello Michela Battipaglia Francesca Mascolo Claudio Iovino Luigi Capasso Carolina Ciacci Nicola Rosa
author_sort	Maddalena De Bernardo
title	Choroidal structural evaluation in celiac disease
title_short	Choroidal structural evaluation in celiac disease
title_full	Choroidal structural evaluation in celiac disease
title_fullStr	Choroidal structural evaluation in celiac disease
title_full_unstemmed	Choroidal structural evaluation in celiac disease
title_sort	choroidal structural evaluation in celiac disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e78b556386fd4d7ca7e78a8582d5ea0d
work_keys_str_mv	AT maddalenadebernardo choroidalstructuralevaluationinceliacdisease AT liviovitiello choroidalstructuralevaluationinceliacdisease AT michelabattipaglia choroidalstructuralevaluationinceliacdisease AT francescamascolo choroidalstructuralevaluationinceliacdisease AT claudioiovino choroidalstructuralevaluationinceliacdisease AT luigicapasso choroidalstructuralevaluationinceliacdisease AT carolinaciacci choroidalstructuralevaluationinceliacdisease AT nicolarosa choroidalstructuralevaluationinceliacdisease
_version_	1718377478296174592

Choroidal structural evaluation in celiac disease

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