STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQ...

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Autores principales:	Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e78e979f7f9a43d280222791ea6273df2021-12-02T17:51:27ZSTAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer10.1038/s41467-021-23396-22041-1723https://doaj.org/article/e78e979f7f9a43d280222791ea6273df2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23396-2https://doaj.org/toc/2041-1723Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQO1.Stephanie P. TottenYoung Kyuen ImEduardo Cepeda CañedoOuafa NajybAlice NguyenSteven HébertRyuhjin AhnKyle LewisBenjamin LebeauRachel La SelvaValérie SabourinConstanza MartínezPaul SavageHellen KuasneDaina AvizonisNancy Santos MartínezCatherine ChabotAdriana Aguilar-MahechaMarie-Line GouletMatthew DanknerMichael WitcherKevin PetreccaMark BasikMichael PollakIvan TopisirovicRongtuan LinPeter M. SiegelClaudia L. KleinmanMorag ParkJulie St-PierreJosie Ursini-SiegelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie P. Totten Young Kyuen Im Eduardo Cepeda Cañedo Ouafa Najyb Alice Nguyen Steven Hébert Ryuhjin Ahn Kyle Lewis Benjamin Lebeau Rachel La Selva Valérie Sabourin Constanza Martínez Paul Savage Hellen Kuasne Daina Avizonis Nancy Santos Martínez Catherine Chabot Adriana Aguilar-Mahecha Marie-Line Goulet Matthew Dankner Michael Witcher Kevin Petrecca Mark Basik Michael Pollak Ivan Topisirovic Rongtuan Lin Peter M. Siegel Claudia L. Kleinman Morag Park Julie St-Pierre Josie Ursini-Siegel STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
description	Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQO1.
format	article
author	Stephanie P. Totten Young Kyuen Im Eduardo Cepeda Cañedo Ouafa Najyb Alice Nguyen Steven Hébert Ryuhjin Ahn Kyle Lewis Benjamin Lebeau Rachel La Selva Valérie Sabourin Constanza Martínez Paul Savage Hellen Kuasne Daina Avizonis Nancy Santos Martínez Catherine Chabot Adriana Aguilar-Mahecha Marie-Line Goulet Matthew Dankner Michael Witcher Kevin Petrecca Mark Basik Michael Pollak Ivan Topisirovic Rongtuan Lin Peter M. Siegel Claudia L. Kleinman Morag Park Julie St-Pierre Josie Ursini-Siegel
author_facet	Stephanie P. Totten Young Kyuen Im Eduardo Cepeda Cañedo Ouafa Najyb Alice Nguyen Steven Hébert Ryuhjin Ahn Kyle Lewis Benjamin Lebeau Rachel La Selva Valérie Sabourin Constanza Martínez Paul Savage Hellen Kuasne Daina Avizonis Nancy Santos Martínez Catherine Chabot Adriana Aguilar-Mahecha Marie-Line Goulet Matthew Dankner Michael Witcher Kevin Petrecca Mark Basik Michael Pollak Ivan Topisirovic Rongtuan Lin Peter M. Siegel Claudia L. Kleinman Morag Park Julie St-Pierre Josie Ursini-Siegel
author_sort	Stephanie P. Totten
title	STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
title_short	STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
title_full	STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
title_fullStr	STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
title_full_unstemmed	STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
title_sort	stat1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
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STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

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