Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound

Abstract Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-c...

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Autores principales:	Xiaoqian Su, Reju George Thomas, Lakshmi Deepika Bharatula, James J. Kwan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e79061d3a37744a9a447a1c7e6c80347
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spelling	oai:doaj.org-article:e79061d3a37744a9a447a1c7e6c803472021-12-02T15:08:07ZRemote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound10.1038/s41598-019-46022-02045-2322https://doaj.org/article/e79061d3a37744a9a447a1c7e6c803472019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46022-0https://doaj.org/toc/2045-2322Abstract Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycolic acid) microparticle (mcPLGA MP) loaded with rhodamine B (RhB) with or without 4′,6-diamidino-2-phenylindole (DAPI) to represent small molecule therapeutics. After exposure to high intensity focused ultrasound (HIFU), these delivery vehicles were remotely implanted into gel and porcine tissue models, where the particles rapidly released their payload within the first day and sustained release for at least seven days. RhB-mcPLGA MPs were implanted with HIFU into and beyond the sub-endothelial space of porcine arteries without observable damage to the artery. HIFU also guided the location of implantation; RhB-mcPLGA MPs were only observed at the focus of the HIFU away from the direction of ultrasound. Once implanted, DAPI co-loaded RhB-mcPLGA MPs released DAPI into the arterial wall, staining the nucleus of the cells. Our work shows the potential for HIFU-guided implantation of drug-loaded particles as a strategy to improve the local and sustained delivery of a therapeutic for up to two weeks.Xiaoqian SuReju George ThomasLakshmi Deepika BharatulaJames J. KwanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoqian Su Reju George Thomas Lakshmi Deepika Bharatula James J. Kwan Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
description	Abstract Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycolic acid) microparticle (mcPLGA MP) loaded with rhodamine B (RhB) with or without 4′,6-diamidino-2-phenylindole (DAPI) to represent small molecule therapeutics. After exposure to high intensity focused ultrasound (HIFU), these delivery vehicles were remotely implanted into gel and porcine tissue models, where the particles rapidly released their payload within the first day and sustained release for at least seven days. RhB-mcPLGA MPs were implanted with HIFU into and beyond the sub-endothelial space of porcine arteries without observable damage to the artery. HIFU also guided the location of implantation; RhB-mcPLGA MPs were only observed at the focus of the HIFU away from the direction of ultrasound. Once implanted, DAPI co-loaded RhB-mcPLGA MPs released DAPI into the arterial wall, staining the nucleus of the cells. Our work shows the potential for HIFU-guided implantation of drug-loaded particles as a strategy to improve the local and sustained delivery of a therapeutic for up to two weeks.
format	article
author	Xiaoqian Su Reju George Thomas Lakshmi Deepika Bharatula James J. Kwan
author_facet	Xiaoqian Su Reju George Thomas Lakshmi Deepika Bharatula James J. Kwan
author_sort	Xiaoqian Su
title	Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
title_short	Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
title_full	Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
title_fullStr	Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
title_full_unstemmed	Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
title_sort	remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e79061d3a37744a9a447a1c7e6c80347
work_keys_str_mv	AT xiaoqiansu remotetargetedimplantationofsoundsensitivebiodegradablemulticavitymicroparticleswithfocusedultrasound AT rejugeorgethomas remotetargetedimplantationofsoundsensitivebiodegradablemulticavitymicroparticleswithfocusedultrasound AT lakshmideepikabharatula remotetargetedimplantationofsoundsensitivebiodegradablemulticavitymicroparticleswithfocusedultrasound AT jamesjkwan remotetargetedimplantationofsoundsensitivebiodegradablemulticavitymicroparticleswithfocusedultrasound
_version_	1718388288093421568

Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound

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