The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.
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Nature Portfolio
2019
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oai:doaj.org-article:e790a9921fd644c2949b6cd1e56876052021-12-02T15:35:26ZThe major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function10.1038/s41467-019-09996-z2041-1723https://doaj.org/article/e790a9921fd644c2949b6cd1e56876052019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09996-zhttps://doaj.org/toc/2041-1723In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.Allison J. BancroftColin W. LevyThomas A. JowittKelly S. HayesSeona ThompsonEdward A. MckenzieMatthew D. BallEamon DubaissiAidan P. FranceBruno BellinaCatherine SharpeAleksandr MironovSheila L. BrownPeter C. CookAndrew S. MacDonaldDavid J. ThorntonRichard K. GrencisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| description |
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies. |
| format |
article |
| author |
Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis |
| author_facet |
Allison J. Bancroft Colin W. Levy Thomas A. Jowitt Kelly S. Hayes Seona Thompson Edward A. Mckenzie Matthew D. Ball Eamon Dubaissi Aidan P. France Bruno Bellina Catherine Sharpe Aleksandr Mironov Sheila L. Brown Peter C. Cook Andrew S. MacDonald David J. Thornton Richard K. Grencis |
| author_sort |
Allison J. Bancroft |
| title |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_short |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_full |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_fullStr |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_full_unstemmed |
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| title_sort |
major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/e790a9921fd644c2949b6cd1e5687605 |
| work_keys_str_mv |
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