Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specific...

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Autores principales:	Anna Rao, Otto Strauss, Efthymia Kokkinou, Mélanie Bruchard, Kumar P. Tripathi, Heinrich Schlums, Anna Carrasco, Luca Mazzurana, Viktoria Konya, Eduardo J. Villablanca, Niklas K. Björkström, Ulrik Lindforss, Hergen Spits, Jenny Mjösberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e79201d95ac34780b172a9be7f149a45
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spelling	oai:doaj.org-article:e79201d95ac34780b172a9be7f149a452021-12-02T15:39:08ZCytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs10.1038/s41467-020-15695-x2041-1723https://doaj.org/article/e79201d95ac34780b172a9be7f149a452020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15695-xhttps://doaj.org/toc/2041-1723Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.Anna RaoOtto StraussEfthymia KokkinouMélanie BruchardKumar P. TripathiHeinrich SchlumsAnna CarrascoLuca MazzuranaViktoria KonyaEduardo J. VillablancaNiklas K. BjörkströmUlrik LindforssHergen SpitsJenny MjösbergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Rao Otto Strauss Efthymia Kokkinou Mélanie Bruchard Kumar P. Tripathi Heinrich Schlums Anna Carrasco Luca Mazzurana Viktoria Konya Eduardo J. Villablanca Niklas K. Björkström Ulrik Lindforss Hergen Spits Jenny Mjösberg Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
description	Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.
format	article
author	Anna Rao Otto Strauss Efthymia Kokkinou Mélanie Bruchard Kumar P. Tripathi Heinrich Schlums Anna Carrasco Luca Mazzurana Viktoria Konya Eduardo J. Villablanca Niklas K. Björkström Ulrik Lindforss Hergen Spits Jenny Mjösberg
author_facet	Anna Rao Otto Strauss Efthymia Kokkinou Mélanie Bruchard Kumar P. Tripathi Heinrich Schlums Anna Carrasco Luca Mazzurana Viktoria Konya Eduardo J. Villablanca Niklas K. Björkström Ulrik Lindforss Hergen Spits Jenny Mjösberg
author_sort	Anna Rao
title	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
title_short	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
title_full	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
title_fullStr	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
title_full_unstemmed	Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
title_sort	cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ilcs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e79201d95ac34780b172a9be7f149a45
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Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

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