The Lst Sialyltransferase of <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content> Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea

The Lst Sialyltransferase of <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content> Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea

ABSTRACT The lipooligosaccharide (LOS) of Neisseria gonorrhoeae plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in the glycosyltransferase gene content of particular strains. LOS glyc...

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Bibliographic Details
Main Authors: Freda E.-C. Jen, Margaret R. Ketterer, Evgeny A. Semchenko, Christopher J. Day, Kate L. Seib, Michael A. Apicella, Michael P. Jennings
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Neisseria gonorrhea
lipooligosaccharide (LOS)
keto-deoxyoctanoate (KDO)
gonococcal vaccine
N-acetylneuraminic acid (Neu5Ac)
sialic acid
Microbiology
QR1-502
Online Access:https://doaj.org/article/e792e6f0b6e749d4b2e0efbf84976f51
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