Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domai...

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Autores principales:	Solmaz Abdolrahimzadeh, Serena Fragiotta, Chiara Ciacimino, Mariachiara Di Pippo, Gianluca Scuderi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adult-onset foveomacular vitelliform dystrophy age-related macular degeneration choroidal thickness choroidal vascularity index conventional drusen spectral domain optical coherence tomography Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e793737141ff40e8bb66443327890f1c
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spelling	oai:doaj.org-article:e793737141ff40e8bb66443327890f1c2021-11-11T15:25:34ZChoroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study10.3390/app1121104872076-3417https://doaj.org/article/e793737141ff40e8bb66443327890f1c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10487https://doaj.org/toc/2076-3417This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, <i>p</i> = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, <i>p</i> = 0.001) than eyes with CD and controls (<i>p</i> = 0.03). No differences in CVI were detected between controls and eyes with CD (<i>p</i> = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, <i>p</i> = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.Solmaz AbdolrahimzadehSerena FragiottaChiara CiaciminoMariachiara Di PippoGianluca ScuderiMDPI AGarticleadult-onset foveomacular vitelliform dystrophyage-related macular degenerationchoroidal thicknesschoroidal vascularity indexconventional drusenspectral domain optical coherence tomographyTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10487, p 10487 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adult-onset foveomacular vitelliform dystrophy age-related macular degeneration choroidal thickness choroidal vascularity index conventional drusen spectral domain optical coherence tomography Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	adult-onset foveomacular vitelliform dystrophy age-related macular degeneration choroidal thickness choroidal vascularity index conventional drusen spectral domain optical coherence tomography Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
description	This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, <i>p</i> = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, <i>p</i> = 0.001) than eyes with CD and controls (<i>p</i> = 0.03). No differences in CVI were detected between controls and eyes with CD (<i>p</i> = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, <i>p</i> = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.
format	article
author	Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi
author_facet	Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi
author_sort	Solmaz Abdolrahimzadeh
title	Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
title_short	Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
title_full	Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
title_fullStr	Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
title_full_unstemmed	Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
title_sort	choroidal vascularity index in adult-onset foveomacular vitelliform dystrophy: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e793737141ff40e8bb66443327890f1c
work_keys_str_mv	AT solmazabdolrahimzadeh choroidalvascularityindexinadultonsetfoveomacularvitelliformdystrophyapilotstudy AT serenafragiotta choroidalvascularityindexinadultonsetfoveomacularvitelliformdystrophyapilotstudy AT chiaraciacimino choroidalvascularityindexinadultonsetfoveomacularvitelliformdystrophyapilotstudy AT mariachiaradipippo choroidalvascularityindexinadultonsetfoveomacularvitelliformdystrophyapilotstudy AT gianlucascuderi choroidalvascularityindexinadultonsetfoveomacularvitelliformdystrophyapilotstudy
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Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

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