Platelet-lymphocyte ratio and sepsis outcome in children

Background Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring syste...

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Autores principales:	Ferry Kurniawan, Jeanette I. Ch. Manoppo, Ari Lukas Runtunuwu, Novie Homenta Rampengan, Julius Lolombulan
Formato:	article
Lenguaje:	EN
Publicado:	Indonesian Pediatric Society Publishing House 2021
Materias:	: sepsis; platelet-lymphocyte ratio; plr; clinical outcomes Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/e7960697994c4c01a7fbca910d5a3b5c
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spelling	oai:doaj.org-article:e7960697994c4c01a7fbca910d5a3b5c2021-11-29T02:29:22ZPlatelet-lymphocyte ratio and sepsis outcome in children0030-93112338-476X10.14238/pi61.6.2021.322-7https://doaj.org/article/e7960697994c4c01a7fbca910d5a3b5c2021-11-01T00:00:00Zhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2618https://doaj.org/toc/0030-9311https://doaj.org/toc/2338-476XBackground Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring systems have been used to determine the prognosis of sepsis n children. The platelet-lymphocyte ratio (PLR), a newly-used marker for inflammation, has received recent attention, as it can act as an indicator in a variety of diseases, including sepsis. Objective o investigate the relationship between PLR and clinical outcomes in pediatric patients with sepsis. Methods This study was conducted using an analytic, observational method with a prospective cohort approach in children with sepsis in the Pediatric Intensive Care Unit (PICU) of Prof. Dr. R. D. Kandou Central General Hospital, Manado, North Sulawesi, from February to August 2020. We analyzed patients’ platelet-lymphocyteratio (PLR), mortality rate, and length of stay using SPSS software. The PLR were recorded once within the first 24 hours of PICU admission. Results Of 96 PICU patients, 87 patients were eligible for this study. In total, 50 patients (57.47%) died. Mean PLR was 77.53 among sepsis survivors and 157.2 among non-survivors (rpb=0.566, P<0.0001) indicating a strong relationship between PLR and mortality. We also found a strong positive linear relationship between PLR and PICU length of stay. Conclusion Platelet-lymphocyte ratio is a predictor of sepsis outcomes that can be easily and inexpensively checked. Thus, it can be used in regions with limited health facilities.Ferry KurniawanJeanette I. Ch. ManoppoAri Lukas RuntunuwuNovie Homenta RampenganJulius LolombulanIndonesian Pediatric Society Publishing Housearticle: sepsis; platelet-lymphocyte ratio; plr; clinical outcomesMedicineRPediatricsRJ1-570ENPaediatrica Indonesiana, Vol 61, Iss 6, Pp 322-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	: sepsis; platelet-lymphocyte ratio; plr; clinical outcomes Medicine R Pediatrics RJ1-570
spellingShingle	: sepsis; platelet-lymphocyte ratio; plr; clinical outcomes Medicine R Pediatrics RJ1-570 Ferry Kurniawan Jeanette I. Ch. Manoppo Ari Lukas Runtunuwu Novie Homenta Rampengan Julius Lolombulan Platelet-lymphocyte ratio and sepsis outcome in children
description	Background Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring systems have been used to determine the prognosis of sepsis n children. The platelet-lymphocyte ratio (PLR), a newly-used marker for inflammation, has received recent attention, as it can act as an indicator in a variety of diseases, including sepsis. Objective o investigate the relationship between PLR and clinical outcomes in pediatric patients with sepsis. Methods This study was conducted using an analytic, observational method with a prospective cohort approach in children with sepsis in the Pediatric Intensive Care Unit (PICU) of Prof. Dr. R. D. Kandou Central General Hospital, Manado, North Sulawesi, from February to August 2020. We analyzed patients’ platelet-lymphocyteratio (PLR), mortality rate, and length of stay using SPSS software. The PLR were recorded once within the first 24 hours of PICU admission. Results Of 96 PICU patients, 87 patients were eligible for this study. In total, 50 patients (57.47%) died. Mean PLR was 77.53 among sepsis survivors and 157.2 among non-survivors (rpb=0.566, P<0.0001) indicating a strong relationship between PLR and mortality. We also found a strong positive linear relationship between PLR and PICU length of stay. Conclusion Platelet-lymphocyte ratio is a predictor of sepsis outcomes that can be easily and inexpensively checked. Thus, it can be used in regions with limited health facilities.
format	article
author	Ferry Kurniawan Jeanette I. Ch. Manoppo Ari Lukas Runtunuwu Novie Homenta Rampengan Julius Lolombulan
author_facet	Ferry Kurniawan Jeanette I. Ch. Manoppo Ari Lukas Runtunuwu Novie Homenta Rampengan Julius Lolombulan
author_sort	Ferry Kurniawan
title	Platelet-lymphocyte ratio and sepsis outcome in children
title_short	Platelet-lymphocyte ratio and sepsis outcome in children
title_full	Platelet-lymphocyte ratio and sepsis outcome in children
title_fullStr	Platelet-lymphocyte ratio and sepsis outcome in children
title_full_unstemmed	Platelet-lymphocyte ratio and sepsis outcome in children
title_sort	platelet-lymphocyte ratio and sepsis outcome in children
publisher	Indonesian Pediatric Society Publishing House
publishDate	2021
url	https://doaj.org/article/e7960697994c4c01a7fbca910d5a3b5c
work_keys_str_mv	AT ferrykurniawan plateletlymphocyteratioandsepsisoutcomeinchildren AT jeanetteichmanoppo plateletlymphocyteratioandsepsisoutcomeinchildren AT arilukasruntunuwu plateletlymphocyteratioandsepsisoutcomeinchildren AT noviehomentarampengan plateletlymphocyteratioandsepsisoutcomeinchildren AT juliuslolombulan plateletlymphocyteratioandsepsisoutcomeinchildren
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Platelet-lymphocyte ratio and sepsis outcome in children

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