Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia

Naoki Goto1, Reiji Yoshimura1, Shingo Kakeda2, Joji Nishimura2, Junji Moriya2, Kenji Hayashi1, Asuka Katsuki1, Hikaru Hori1, Wakako Umene-Nakano1, Atsuko Ikenouchi-Sugita1, Yukunori Korogi2, Jun Nakamura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fuku...

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Autores principales:	Goto N, Yoshimura R, Kakeda S, Nishimura J, Moriya J, Hayashi K, Katsuki A, Hori H, Umen-Nakano W, Ikenouchi-Sugita A, Korogi Y, Nakamura J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e799eaf2923445b3a4f02448c170c458
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spelling	oai:doaj.org-article:e799eaf2923445b3a4f02448c170c4582021-12-02T02:43:49ZSix-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia1176-63281178-2021https://doaj.org/article/e799eaf2923445b3a4f02448c170c4582012-04-01T00:00:00Zhttp://www.dovepress.com/six-month-treatment-with-atypical-antipsychotic-drugs-decreased-fronta-a9618https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Naoki Goto1, Reiji Yoshimura1, Shingo Kakeda2, Joji Nishimura2, Junji Moriya2, Kenji Hayashi1, Asuka Katsuki1, Hikaru Hori1, Wakako Umene-Nakano1, Atsuko Ikenouchi-Sugita1, Yukunori Korogi2, Jun Nakamura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan; 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, JapanObjective: To study the effects of treatment with atypical antipsychotic drugs on brain levels of glutamate plus glutamine in early-stage first-episode schizophrenia.Participants: Sixteen patients (eight males, eight females; aged 30 &plusmn; 11 years) completed the study.Methods: We used administered 6 months of atypical antipsychotic drugs and used proton magnetic resonance spectroscopy to evaluate the results.Results: We found that the administration of atypical antipsychotic drugs for 6 months decreased the glutamate plus glutamine/creatine ratio in the frontal lobe. These results suggest that the administration of atypical antipsychotic drugs for at least 6 months decreased glutamatergic neurotransmissions in the frontal lobe in early-stage first-episode schizophrenia, but there was no difference in frontal-lobe levels between patients and control subjects before administration.Conclusion: Taking these findings into account, the glutamatergic and GABAergic neurons are implicated in early-stage first-episode schizophrenia, but in complex ways.Keywords: Proton magnetic resonance spectroscopy, creatine, frontal lobe, parieto-occipital node, left basal gangliaGoto NYoshimura RKakeda SNishimura JMoriya JHayashi KKatsuki AHori HUmen-Nakano WIkenouchi-Sugita AKorogi YNakamura JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 119-122 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Goto N Yoshimura R Kakeda S Nishimura J Moriya J Hayashi K Katsuki A Hori H Umen-Nakano W Ikenouchi-Sugita A Korogi Y Nakamura J Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
description	Naoki Goto1, Reiji Yoshimura1, Shingo Kakeda2, Joji Nishimura2, Junji Moriya2, Kenji Hayashi1, Asuka Katsuki1, Hikaru Hori1, Wakako Umene-Nakano1, Atsuko Ikenouchi-Sugita1, Yukunori Korogi2, Jun Nakamura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan; 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, JapanObjective: To study the effects of treatment with atypical antipsychotic drugs on brain levels of glutamate plus glutamine in early-stage first-episode schizophrenia.Participants: Sixteen patients (eight males, eight females; aged 30 &plusmn; 11 years) completed the study.Methods: We used administered 6 months of atypical antipsychotic drugs and used proton magnetic resonance spectroscopy to evaluate the results.Results: We found that the administration of atypical antipsychotic drugs for 6 months decreased the glutamate plus glutamine/creatine ratio in the frontal lobe. These results suggest that the administration of atypical antipsychotic drugs for at least 6 months decreased glutamatergic neurotransmissions in the frontal lobe in early-stage first-episode schizophrenia, but there was no difference in frontal-lobe levels between patients and control subjects before administration.Conclusion: Taking these findings into account, the glutamatergic and GABAergic neurons are implicated in early-stage first-episode schizophrenia, but in complex ways.Keywords: Proton magnetic resonance spectroscopy, creatine, frontal lobe, parieto-occipital node, left basal ganglia
format	article
author	Goto N Yoshimura R Kakeda S Nishimura J Moriya J Hayashi K Katsuki A Hori H Umen-Nakano W Ikenouchi-Sugita A Korogi Y Nakamura J
author_facet	Goto N Yoshimura R Kakeda S Nishimura J Moriya J Hayashi K Katsuki A Hori H Umen-Nakano W Ikenouchi-Sugita A Korogi Y Nakamura J
author_sort	Goto N
title	Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
title_short	Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
title_full	Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
title_fullStr	Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
title_full_unstemmed	Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
title_sort	six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/e799eaf2923445b3a4f02448c170c458
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Six-month treatment with atypical antipsychotic drugs decreased frontal-lobe levels of glutamate plus glutamine in early-stage first-episode schizophrenia

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