Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays

A set of CALUX in vitro bioassays was applied for long-term toxicity monitoring at an advanced wastewater treatment plant comprising ozonation and granular activated carbon filtration for the abatement of contaminants of emerging concern (CEC). During the 13-month monitoring, eight reporter gene ass...

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Autores principales:	Lam T. Phan, Heidemarie Schaar, Daniela Reif, Sascha Weilguni, Ernis Saracevic, Jörg Krampe, Peter A. Behnisch, Norbert Kreuzinger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ozonation granular activated carbon CALUX reporter gene bioassays effect-based trigger value urban wastewater Hydraulic engineering TC1-978 Water supply for domestic and industrial purposes TD201-500
Acceso en línea:	https://doaj.org/article/e79a3707b86e44b4bf2b8c9e0b65d2ec
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spelling	oai:doaj.org-article:e79a3707b86e44b4bf2b8c9e0b65d2ec2021-11-25T19:15:56ZLong-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays10.3390/w132232452073-4441https://doaj.org/article/e79a3707b86e44b4bf2b8c9e0b65d2ec2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4441/13/22/3245https://doaj.org/toc/2073-4441A set of CALUX in vitro bioassays was applied for long-term toxicity monitoring at an advanced wastewater treatment plant comprising ozonation and granular activated carbon filtration for the abatement of contaminants of emerging concern (CEC). During the 13-month monitoring, eight reporter gene assays targeting different modes of action along the cellular toxicity pathway were accessed to evaluate the suitability and robustness of the technologies. Two approaches were followed: on the one hand, signal reduction during advanced treatment was monitored; on the other hand, results were compared to currently available effect-based trigger values (EBTs). A decrease of the corresponding biological equivalent concentrations after the multibarrier system could be observed for all modes of action; while the estrogenic activity decreased below the EBT already during ozonation, the potencies of oxidative stress-like and toxic PAH-like compounds still exceeded the discussed EBT after advanced treatment. Overall, the long-term monitoring confirmed the positive effect of the multibarrier system, commonly evaluated only by CEC abatement based on chemical analysis. It could be demonstrated that advanced WWTPs designed for CEC abatement are suitable to significantly decrease toxicity responses not only in the frame of pilot studies but under real-world conditions as well.Lam T. PhanHeidemarie SchaarDaniela ReifSascha WeilguniErnis SaracevicJörg KrampePeter A. BehnischNorbert KreuzingerMDPI AGarticleozonationgranular activated carbonCALUX reporter gene bioassayseffect-based trigger valueurban wastewaterHydraulic engineeringTC1-978Water supply for domestic and industrial purposesTD201-500ENWater, Vol 13, Iss 3245, p 3245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ozonation granular activated carbon CALUX reporter gene bioassays effect-based trigger value urban wastewater Hydraulic engineering TC1-978 Water supply for domestic and industrial purposes TD201-500
spellingShingle	ozonation granular activated carbon CALUX reporter gene bioassays effect-based trigger value urban wastewater Hydraulic engineering TC1-978 Water supply for domestic and industrial purposes TD201-500 Lam T. Phan Heidemarie Schaar Daniela Reif Sascha Weilguni Ernis Saracevic Jörg Krampe Peter A. Behnisch Norbert Kreuzinger Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
description	A set of CALUX in vitro bioassays was applied for long-term toxicity monitoring at an advanced wastewater treatment plant comprising ozonation and granular activated carbon filtration for the abatement of contaminants of emerging concern (CEC). During the 13-month monitoring, eight reporter gene assays targeting different modes of action along the cellular toxicity pathway were accessed to evaluate the suitability and robustness of the technologies. Two approaches were followed: on the one hand, signal reduction during advanced treatment was monitored; on the other hand, results were compared to currently available effect-based trigger values (EBTs). A decrease of the corresponding biological equivalent concentrations after the multibarrier system could be observed for all modes of action; while the estrogenic activity decreased below the EBT already during ozonation, the potencies of oxidative stress-like and toxic PAH-like compounds still exceeded the discussed EBT after advanced treatment. Overall, the long-term monitoring confirmed the positive effect of the multibarrier system, commonly evaluated only by CEC abatement based on chemical analysis. It could be demonstrated that advanced WWTPs designed for CEC abatement are suitable to significantly decrease toxicity responses not only in the frame of pilot studies but under real-world conditions as well.
format	article
author	Lam T. Phan Heidemarie Schaar Daniela Reif Sascha Weilguni Ernis Saracevic Jörg Krampe Peter A. Behnisch Norbert Kreuzinger
author_facet	Lam T. Phan Heidemarie Schaar Daniela Reif Sascha Weilguni Ernis Saracevic Jörg Krampe Peter A. Behnisch Norbert Kreuzinger
author_sort	Lam T. Phan
title	Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
title_short	Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
title_full	Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
title_fullStr	Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
title_full_unstemmed	Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays
title_sort	long-term toxicological monitoring of a multibarrier advanced wastewater treatment plant comprising ozonation and granular activated carbon with in vitro bioassays
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e79a3707b86e44b4bf2b8c9e0b65d2ec
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Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays

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