A tunable dual-input system for on-demand dynamic gene expression regulation

Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.

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Autores principales:	Elisa Pedone, Lorena Postiglione, Francesco Aulicino, Dan L. Rocca, Sandra Montes-Olivas, Mahmoud Khazim, Diego di Bernardo, Maria Pia Cosma, Lucia Marucci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e79a3cc6f3294f59896d1257115ecf15
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spelling	oai:doaj.org-article:e79a3cc6f3294f59896d1257115ecf152021-12-02T17:31:52ZA tunable dual-input system for on-demand dynamic gene expression regulation10.1038/s41467-019-12329-92041-1723https://doaj.org/article/e79a3cc6f3294f59896d1257115ecf152019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12329-9https://doaj.org/toc/2041-1723Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.Elisa PedoneLorena PostiglioneFrancesco AulicinoDan L. RoccaSandra Montes-OlivasMahmoud KhazimDiego di BernardoMaria Pia CosmaLucia MarucciNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci A tunable dual-input system for on-demand dynamic gene expression regulation
description	Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.
format	article
author	Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci
author_facet	Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci
author_sort	Elisa Pedone
title	A tunable dual-input system for on-demand dynamic gene expression regulation
title_short	A tunable dual-input system for on-demand dynamic gene expression regulation
title_full	A tunable dual-input system for on-demand dynamic gene expression regulation
title_fullStr	A tunable dual-input system for on-demand dynamic gene expression regulation
title_full_unstemmed	A tunable dual-input system for on-demand dynamic gene expression regulation
title_sort	tunable dual-input system for on-demand dynamic gene expression regulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e79a3cc6f3294f59896d1257115ecf15
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A tunable dual-input system for on-demand dynamic gene expression regulation

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