Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a stereoselective iso-Pictet-Spengler cyclization.

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Autores principales:	Shi-Ming Xu, Liang Wei, Chong Shen, Lu Xiao, Hai-Yan Tao, Chun-Jiang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e79dc2021cf04aeb843a77e7163965de
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spelling	oai:doaj.org-article:e79dc2021cf04aeb843a77e7163965de2021-12-02T16:50:57ZStereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction10.1038/s41467-019-13529-z2041-1723https://doaj.org/article/e79dc2021cf04aeb843a77e7163965de2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13529-zhttps://doaj.org/toc/2041-1723Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a stereoselective iso-Pictet-Spengler cyclization.Shi-Ming XuLiang WeiChong ShenLu XiaoHai-Yan TaoChun-Jiang WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shi-Ming Xu Liang Wei Chong Shen Lu Xiao Hai-Yan Tao Chun-Jiang Wang Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
description	Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a stereoselective iso-Pictet-Spengler cyclization.
format	article
author	Shi-Ming Xu Liang Wei Chong Shen Lu Xiao Hai-Yan Tao Chun-Jiang Wang
author_facet	Shi-Ming Xu Liang Wei Chong Shen Lu Xiao Hai-Yan Tao Chun-Jiang Wang
author_sort	Shi-Ming Xu
title	Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
title_short	Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
title_full	Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
title_fullStr	Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
title_full_unstemmed	Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
title_sort	stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e79dc2021cf04aeb843a77e7163965de
work_keys_str_mv	AT shimingxu stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction AT liangwei stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction AT chongshen stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction AT luxiao stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction AT haiyantao stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction AT chunjiangwang stereodivergentassemblyoftetrahydrogcarbolinesviasynergisticcatalyticasymmetriccascadereaction
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Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

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