Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae

Abstract. Cristianawati O, Sabdaningsih A, Becking LE, Khoeri MM, Nuryadi H, Sabdono A, Trianto A, Radjasa OK. 2019. Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae. Biodiversitas 20: 2143-2150. Threats of drug-resistant...

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Autores principales:	Olvi Cristianawati, Aninditia Sabdaningsih, Leontine Elisabeth Becking, Miftahudin Majid Khoeri, Handung Nuryadi, Agus Sabdono, AGUS TRIANTO, OCKY KARNA RADJASA
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2019
Materias:	cinachyrella australiensis, curvularia lunata, streptococcus pneumoniae, marine derived-fungi Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e79fa429bd1c4f26bf255abb1ce99b45
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spelling	oai:doaj.org-article:e79fa429bd1c4f26bf255abb1ce99b452021-11-21T21:43:55ZBiological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae1412-033X2085-472210.13057/biodiv/d200807https://doaj.org/article/e79fa429bd1c4f26bf255abb1ce99b452019-07-01T00:00:00Zhttps://smujo.id/biodiv/article/view/4033https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Cristianawati O, Sabdaningsih A, Becking LE, Khoeri MM, Nuryadi H, Sabdono A, Trianto A, Radjasa OK. 2019. Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae. Biodiversitas 20: 2143-2150. Threats of drug-resistant Streptococcus pneumoniae and the urgent need for new antibiotics require prompt and sustained action for discovering bioactive compounds. This study aimed to isolate sponge-associated fungi as a candidate for sources of drugs. The sponge-associated fungi were screened against the MDR S. pneumoniae. The Deoxyribonucleic Acid (DNA) of fungal isolates that showed the most active was generated by using universal primers ITS1 and ITS4. While the sponge host was identified based on the molecular and by slide section. Out of twenty-nine fungal isolates from 13 marine sponges, S.06.2 isolate produced secondary metabolite that inhibiting the growth of MDR S. pneumoniae. Molecular identification based on the ITS region revealed that the active fungal isolate was closely related to Curvularia lunata, with a 99% similarity. The C. lunata S.06.2 was isolated from sponge Cinachyrella australiensis. Thus, C. lunata S.06.2_ LC315806 can serve as a fruitful strategy for the discovery of novel antibiotics for the treatment of MDR S. pneumoniae.Olvi CristianawatiAninditia SabdaningsihLeontine Elisabeth BeckingMiftahudin Majid KhoeriHandung NuryadiAgus SabdonoAGUS TRIANTOOCKY KARNA RADJASAMBI & UNS Soloarticlecinachyrella australiensis, curvularia lunata, streptococcus pneumoniae, marine derived-fungiBiology (General)QH301-705.5ENBiodiversitas, Vol 20, Iss 8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cinachyrella australiensis, curvularia lunata, streptococcus pneumoniae, marine derived-fungi Biology (General) QH301-705.5
spellingShingle	cinachyrella australiensis, curvularia lunata, streptococcus pneumoniae, marine derived-fungi Biology (General) QH301-705.5 Olvi Cristianawati Aninditia Sabdaningsih Leontine Elisabeth Becking Miftahudin Majid Khoeri Handung Nuryadi Agus Sabdono AGUS TRIANTO OCKY KARNA RADJASA Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
description	Abstract. Cristianawati O, Sabdaningsih A, Becking LE, Khoeri MM, Nuryadi H, Sabdono A, Trianto A, Radjasa OK. 2019. Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae. Biodiversitas 20: 2143-2150. Threats of drug-resistant Streptococcus pneumoniae and the urgent need for new antibiotics require prompt and sustained action for discovering bioactive compounds. This study aimed to isolate sponge-associated fungi as a candidate for sources of drugs. The sponge-associated fungi were screened against the MDR S. pneumoniae. The Deoxyribonucleic Acid (DNA) of fungal isolates that showed the most active was generated by using universal primers ITS1 and ITS4. While the sponge host was identified based on the molecular and by slide section. Out of twenty-nine fungal isolates from 13 marine sponges, S.06.2 isolate produced secondary metabolite that inhibiting the growth of MDR S. pneumoniae. Molecular identification based on the ITS region revealed that the active fungal isolate was closely related to Curvularia lunata, with a 99% similarity. The C. lunata S.06.2 was isolated from sponge Cinachyrella australiensis. Thus, C. lunata S.06.2_ LC315806 can serve as a fruitful strategy for the discovery of novel antibiotics for the treatment of MDR S. pneumoniae.
format	article
author	Olvi Cristianawati Aninditia Sabdaningsih Leontine Elisabeth Becking Miftahudin Majid Khoeri Handung Nuryadi Agus Sabdono AGUS TRIANTO OCKY KARNA RADJASA
author_facet	Olvi Cristianawati Aninditia Sabdaningsih Leontine Elisabeth Becking Miftahudin Majid Khoeri Handung Nuryadi Agus Sabdono AGUS TRIANTO OCKY KARNA RADJASA
author_sort	Olvi Cristianawati
title	Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
title_short	Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
title_full	Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
title_fullStr	Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
title_full_unstemmed	Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae
title_sort	biological activity of sponge-associated fungi from karimunjawa islands, indonesia against pathogenic streptococcus pneumoniae
publisher	MBI & UNS Solo
publishDate	2019
url	https://doaj.org/article/e79fa429bd1c4f26bf255abb1ce99b45
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Biological activity of sponge-associated fungi from Karimunjawa Islands, Indonesia against pathogenic Streptococcus pneumoniae

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