Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain. An increasing amount of data suggests that extracellular vesicles (EVs), i.e., membrane derived vesicles that inherently protect...

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Auteurs principaux:	Marie J. Pauwels, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	extracellular vesicles brain targeting drug delivery neurological disorders brain barriers Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/e7a441730e224e57b41c1cc1ac4d03c7
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spelling	oai:doaj.org-article:e7a441730e224e57b41c1cc1ac4d03c72021-11-25T16:51:34ZSpecial delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain10.3390/biomedicines91117342227-9059https://doaj.org/article/e7a441730e224e57b41c1cc1ac4d03c72021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1734https://doaj.org/toc/2227-9059The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain. An increasing amount of data suggests that extracellular vesicles (EVs), i.e., membrane derived vesicles that inherently protect and transfer biological cargoes between cells, naturally cross the CNS barriers. Moreover, EVs can be engineered with targeting ligands to obtain enriched tissue targeting and delivery capacities. In this review, we provide a detailed overview of the literature describing a natural and engineered CNS targeting and therapeutic efficiency of different cell type derived EVs. Hereby, we specifically focus on peripheral administration routes in a broad range of CNS diseases. Furthermore, we underline the potential of research aimed at elucidating the vesicular transport mechanisms across the different CNS barriers. Finally, we elaborate on the practical considerations towards the application of EVs as a brain drug delivery system.Marie J. PauwelsCharysse VandendriesscheRoosmarijn E. VandenbrouckeMDPI AGarticleextracellular vesiclesbrain targetingdrug deliveryneurological disordersbrain barriersBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1734, p 1734 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles brain targeting drug delivery neurological disorders brain barriers Biology (General) QH301-705.5
spellingShingle	extracellular vesicles brain targeting drug delivery neurological disorders brain barriers Biology (General) QH301-705.5 Marie J. Pauwels Charysse Vandendriessche Roosmarijn E. Vandenbroucke Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
description	The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain. An increasing amount of data suggests that extracellular vesicles (EVs), i.e., membrane derived vesicles that inherently protect and transfer biological cargoes between cells, naturally cross the CNS barriers. Moreover, EVs can be engineered with targeting ligands to obtain enriched tissue targeting and delivery capacities. In this review, we provide a detailed overview of the literature describing a natural and engineered CNS targeting and therapeutic efficiency of different cell type derived EVs. Hereby, we specifically focus on peripheral administration routes in a broad range of CNS diseases. Furthermore, we underline the potential of research aimed at elucidating the vesicular transport mechanisms across the different CNS barriers. Finally, we elaborate on the practical considerations towards the application of EVs as a brain drug delivery system.
format	article
author	Marie J. Pauwels Charysse Vandendriessche Roosmarijn E. Vandenbroucke
author_facet	Marie J. Pauwels Charysse Vandendriessche Roosmarijn E. Vandenbroucke
author_sort	Marie J. Pauwels
title	Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
title_short	Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
title_full	Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
title_fullStr	Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
title_full_unstemmed	Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
title_sort	special delevery: extracellular vesicles as promising delivery platform to the brain
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e7a441730e224e57b41c1cc1ac4d03c7
work_keys_str_mv	AT mariejpauwels specialdeleveryextracellularvesiclesaspromisingdeliveryplatformtothebrain AT charyssevandendriessche specialdeleveryextracellularvesiclesaspromisingdeliveryplatformtothebrain AT roosmarijnevandenbroucke specialdeleveryextracellularvesiclesaspromisingdeliveryplatformtothebrain
_version_	1718412930465136640

Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

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