Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.

In recent years, many studies have found that mechanical tension can activiate NF-kB signal pathway and NF-kB plays an important role in the process of osteogenesis. However, it is still unclear whether this process exists in the anterior palatal suture expansion. In this paper, we mainly studied th...

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Autores principales:	Yafang Li, Yiqiang Qiao, Huanhuan Wang, Zao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7a4bb1a0c3d413d8954997b0f705e72
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spelling	oai:doaj.org-article:e7a4bb1a0c3d413d8954997b0f705e722021-12-02T20:05:08ZIntraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.1932-620310.1371/journal.pone.0243108https://doaj.org/article/e7a4bb1a0c3d413d8954997b0f705e722021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0243108https://doaj.org/toc/1932-6203In recent years, many studies have found that mechanical tension can activiate NF-kB signal pathway and NF-kB plays an important role in the process of osteogenesis. However, it is still unclear whether this process exists in the anterior palatal suture expansion. In this paper, we mainly studied the effect of intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis index of the anterior palatal suture expansion model in young adult rats. The expansion model is grouped and established: 45 male 8-week-old Sprague-Dawley rats were randomly divided into three groups, an expansion only (EO) group, an expansion plus PDTC (PE) group, and a control group. The results revealed that PDTC inhibited the activity of NF-kB signaling pathway and promote one morphogenetic protein 2 (BMP-2), steocalatin (OCN) expression. Compared with the control group, the optical density (OD) value of BMP in the EO group and PE group rats increased significantly from the first day to the seventh day, and the difference was statistically significant (P<0.05). After 6.0Gy irradiation, PDTC administration group could slightly increase the total SOD level in the liver and serum of rats, and reduce the MDA level in the liver and serum, especially the effect of 60mg/kg and 90mg/kg was the most obvious.Yafang LiYiqiang QiaoHuanhuan WangZao WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0243108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yafang Li Yiqiang Qiao Huanhuan Wang Zao Wang Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
description	In recent years, many studies have found that mechanical tension can activiate NF-kB signal pathway and NF-kB plays an important role in the process of osteogenesis. However, it is still unclear whether this process exists in the anterior palatal suture expansion. In this paper, we mainly studied the effect of intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis index of the anterior palatal suture expansion model in young adult rats. The expansion model is grouped and established: 45 male 8-week-old Sprague-Dawley rats were randomly divided into three groups, an expansion only (EO) group, an expansion plus PDTC (PE) group, and a control group. The results revealed that PDTC inhibited the activity of NF-kB signaling pathway and promote one morphogenetic protein 2 (BMP-2), steocalatin (OCN) expression. Compared with the control group, the optical density (OD) value of BMP in the EO group and PE group rats increased significantly from the first day to the seventh day, and the difference was statistically significant (P<0.05). After 6.0Gy irradiation, PDTC administration group could slightly increase the total SOD level in the liver and serum of rats, and reduce the MDA level in the liver and serum, especially the effect of 60mg/kg and 90mg/kg was the most obvious.
format	article
author	Yafang Li Yiqiang Qiao Huanhuan Wang Zao Wang
author_facet	Yafang Li Yiqiang Qiao Huanhuan Wang Zao Wang
author_sort	Yafang Li
title	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
title_short	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
title_full	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
title_fullStr	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
title_full_unstemmed	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
title_sort	intraperitoneal injection of pdtc on the nf-kb signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e7a4bb1a0c3d413d8954997b0f705e72
work_keys_str_mv	AT yafangli intraperitonealinjectionofpdtconthenfkbsignalingpathwayandosteogenesisindexesofyoungadultratswithanteriorpalatalsutureexpansionmodel AT yiqiangqiao intraperitonealinjectionofpdtconthenfkbsignalingpathwayandosteogenesisindexesofyoungadultratswithanteriorpalatalsutureexpansionmodel AT huanhuanwang intraperitonealinjectionofpdtconthenfkbsignalingpathwayandosteogenesisindexesofyoungadultratswithanteriorpalatalsutureexpansionmodel AT zaowang intraperitonealinjectionofpdtconthenfkbsignalingpathwayandosteogenesisindexesofyoungadultratswithanteriorpalatalsutureexpansionmodel
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Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.

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