Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent

Oral supplementation with the amino acid arginine, the precursor of the vasodilator nitric oxide (NO), is associated with a reduction in blood pressure (BP). However, it is uncertain whether a decreased plasma arginine concentration predicts increases in BP. We assessed the relationship between fast...

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Autores principales:	Cameron Naidoo, Alan D. Cromarty, Tracy Snyman, Karen Sliwa, Elena Libhaber, Mohammed R. Essop, Geoffrey P. Candy
Formato:	article
Lenguaje:	EN
Publicado:	South African Heart Association 2017
Materias:	blood pressure cardiovascular disease plasma arginine concentrations Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e7a956a9e7da4a47ae3ef537d256b496
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spelling	oai:doaj.org-article:e7a956a9e7da4a47ae3ef537d256b4962021-11-22T08:03:46ZRelationships between plasma amino acid concentrations and blood pressure in South Africans of African descent10.24170/6-3-19821996-67412071-4602https://doaj.org/article/e7a956a9e7da4a47ae3ef537d256b4962017-04-01T00:00:00Zhttps://www.journals.ac.za/index.php/SAHJ/article/view/1982https://doaj.org/toc/1996-6741https://doaj.org/toc/2071-4602Oral supplementation with the amino acid arginine, the precursor of the vasodilator nitric oxide (NO), is associated with a reduction in blood pressure (BP). However, it is uncertain whether a decreased plasma arginine concentration predicts increases in BP. We assessed the relationship between fasting plasma arginine or other amino acid concentrations and 24 hour ambulatory BP in 75 nevertreated participants recruited from the Johannesburg area, 55 of whom were male. Plasma amino acid concentrations were measured with high performance liquid chromatography-mass-spectrometry. Plasma arginine concentrations were not inversely correlated with ambulatory BP. However, plasma arginine concentrations were increased in 36 participants with a mean daytime systolic BP >140 mm Hg (61 ± 17 μmol/L) as compared to the remaining participants (54 ± 15 μmol/L, p‹0.05). Moreover, plasma arginine concentrations were positively correlated with 24-hour diastolic BP (r=0.26, p‹0.05). In males with a BMI‹30kg/m2, plasma arginine concentrations were positively correlated with both night diastolic (r=0.46, p‹0.005) and systolic (r=0.42, p‹0.005) BP. In a multivariate model with adjustments for age gender, body mass index, and other amino acid concentrations, plasma arginine concentrations were independently and positively associated with night diastolic BP (p‹0.05). In conclusion plasma arginine concentrations are positively associated with ambulatory BP in a group of participants of African descent in South Africa. These data do not support the notion that deficiencies of arginine, the amino acid substrate for NO, are related to increases in BP in groups of African ancestry living in South Africa. However, as with other ethnic groups, the positive relationship between plasma arginine concentrations and BP suggests a reduced capacity to utilise the amino acid substrate for NO synthesis.Cameron NaidooAlan D. CromartyTracy SnymanKaren SliwaElena LibhaberMohammed R. EssopGeoffrey P. CandySouth African Heart Associationarticleblood pressurecardiovascular diseaseplasma arginine concentrationsDiseases of the circulatory (Cardiovascular) systemRC666-701ENSA Heart Journal, Vol 6, Iss 3, Pp 142-147 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood pressure cardiovascular disease plasma arginine concentrations Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	blood pressure cardiovascular disease plasma arginine concentrations Diseases of the circulatory (Cardiovascular) system RC666-701 Cameron Naidoo Alan D. Cromarty Tracy Snyman Karen Sliwa Elena Libhaber Mohammed R. Essop Geoffrey P. Candy Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
description	Oral supplementation with the amino acid arginine, the precursor of the vasodilator nitric oxide (NO), is associated with a reduction in blood pressure (BP). However, it is uncertain whether a decreased plasma arginine concentration predicts increases in BP. We assessed the relationship between fasting plasma arginine or other amino acid concentrations and 24 hour ambulatory BP in 75 nevertreated participants recruited from the Johannesburg area, 55 of whom were male. Plasma amino acid concentrations were measured with high performance liquid chromatography-mass-spectrometry. Plasma arginine concentrations were not inversely correlated with ambulatory BP. However, plasma arginine concentrations were increased in 36 participants with a mean daytime systolic BP >140 mm Hg (61 ± 17 μmol/L) as compared to the remaining participants (54 ± 15 μmol/L, p‹0.05). Moreover, plasma arginine concentrations were positively correlated with 24-hour diastolic BP (r=0.26, p‹0.05). In males with a BMI‹30kg/m2, plasma arginine concentrations were positively correlated with both night diastolic (r=0.46, p‹0.005) and systolic (r=0.42, p‹0.005) BP. In a multivariate model with adjustments for age gender, body mass index, and other amino acid concentrations, plasma arginine concentrations were independently and positively associated with night diastolic BP (p‹0.05). In conclusion plasma arginine concentrations are positively associated with ambulatory BP in a group of participants of African descent in South Africa. These data do not support the notion that deficiencies of arginine, the amino acid substrate for NO, are related to increases in BP in groups of African ancestry living in South Africa. However, as with other ethnic groups, the positive relationship between plasma arginine concentrations and BP suggests a reduced capacity to utilise the amino acid substrate for NO synthesis.
format	article
author	Cameron Naidoo Alan D. Cromarty Tracy Snyman Karen Sliwa Elena Libhaber Mohammed R. Essop Geoffrey P. Candy
author_facet	Cameron Naidoo Alan D. Cromarty Tracy Snyman Karen Sliwa Elena Libhaber Mohammed R. Essop Geoffrey P. Candy
author_sort	Cameron Naidoo
title	Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
title_short	Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
title_full	Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
title_fullStr	Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
title_full_unstemmed	Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent
title_sort	relationships between plasma amino acid concentrations and blood pressure in south africans of african descent
publisher	South African Heart Association
publishDate	2017
url	https://doaj.org/article/e7a956a9e7da4a47ae3ef537d256b496
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Relationships between plasma amino acid concentrations and blood pressure in South Africans of African descent

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