CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer

CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer

Prostate cancer risk-associated SNPs are enriched in noncoding CREs. Here the authors perform CRISPRi screens of CREs in prostate cancer cell lines to describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D genome architecture.

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Autores principales: Musaddeque Ahmed, Fraser Soares, Ji-Han Xia, Yue Yang, Jing Li, Haiyang Guo, Peiran Su, Yijun Tian, Hyung Joo Lee, Miranda Wang, Nayeema Akhtar, Kathleen E. Houlahan, Almudena Bosch, Stanley Zhou, Parisa Mazrooei, Junjie T. Hua, Sujun Chen, Jessica Petricca, Yong Zeng, Alastair Davies, Michael Fraser, David A. Quigley, Felix Y. Feng, Paul C. Boutros, Mathieu Lupien, Amina Zoubeidi, Liang Wang, Martin J. Walsh, Ting Wang, Shancheng Ren, Gong-Hong Wei, Housheng Hansen He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e7aa25730939461e8ebe506e7b821266
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spelling oai:doaj.org-article:e7aa25730939461e8ebe506e7b8212662021-12-02T11:39:37ZCRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer10.1038/s41467-021-21867-02041-1723https://doaj.org/article/e7aa25730939461e8ebe506e7b8212662021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21867-0https://doaj.org/toc/2041-1723Prostate cancer risk-associated SNPs are enriched in noncoding CREs. Here the authors perform CRISPRi screens of CREs in prostate cancer cell lines to describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D genome architecture.Musaddeque AhmedFraser SoaresJi-Han XiaYue YangJing LiHaiyang GuoPeiran SuYijun TianHyung Joo LeeMiranda WangNayeema AkhtarKathleen E. HoulahanAlmudena BoschStanley ZhouParisa MazrooeiJunjie T. HuaSujun ChenJessica PetriccaYong ZengAlastair DaviesMichael FraserDavid A. QuigleyFelix Y. FengPaul C. BoutrosMathieu LupienAmina ZoubeidiLiang WangMartin J. WalshTing WangShancheng RenGong-Hong WeiHousheng Hansen HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Musaddeque Ahmed
Fraser Soares
Ji-Han Xia
Yue Yang
Jing Li
Haiyang Guo
Peiran Su
Yijun Tian
Hyung Joo Lee
Miranda Wang
Nayeema Akhtar
Kathleen E. Houlahan
Almudena Bosch
Stanley Zhou
Parisa Mazrooei
Junjie T. Hua
Sujun Chen
Jessica Petricca
Yong Zeng
Alastair Davies
Michael Fraser
David A. Quigley
Felix Y. Feng
Paul C. Boutros
Mathieu Lupien
Amina Zoubeidi
Liang Wang
Martin J. Walsh
Ting Wang
Shancheng Ren
Gong-Hong Wei
Housheng Hansen He
CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
description Prostate cancer risk-associated SNPs are enriched in noncoding CREs. Here the authors perform CRISPRi screens of CREs in prostate cancer cell lines to describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D genome architecture.
format article
author Musaddeque Ahmed
Fraser Soares
Ji-Han Xia
Yue Yang
Jing Li
Haiyang Guo
Peiran Su
Yijun Tian
Hyung Joo Lee
Miranda Wang
Nayeema Akhtar
Kathleen E. Houlahan
Almudena Bosch
Stanley Zhou
Parisa Mazrooei
Junjie T. Hua
Sujun Chen
Jessica Petricca
Yong Zeng
Alastair Davies
Michael Fraser
David A. Quigley
Felix Y. Feng
Paul C. Boutros
Mathieu Lupien
Amina Zoubeidi
Liang Wang
Martin J. Walsh
Ting Wang
Shancheng Ren
Gong-Hong Wei
Housheng Hansen He
author_facet Musaddeque Ahmed
Fraser Soares
Ji-Han Xia
Yue Yang
Jing Li
Haiyang Guo
Peiran Su
Yijun Tian
Hyung Joo Lee
Miranda Wang
Nayeema Akhtar
Kathleen E. Houlahan
Almudena Bosch
Stanley Zhou
Parisa Mazrooei
Junjie T. Hua
Sujun Chen
Jessica Petricca
Yong Zeng
Alastair Davies
Michael Fraser
David A. Quigley
Felix Y. Feng
Paul C. Boutros
Mathieu Lupien
Amina Zoubeidi
Liang Wang
Martin J. Walsh
Ting Wang
Shancheng Ren
Gong-Hong Wei
Housheng Hansen He
author_sort Musaddeque Ahmed
title CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
title_short CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
title_full CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
title_fullStr CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
title_full_unstemmed CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
title_sort crispri screens reveal a dna methylation-mediated 3d genome dependent causal mechanism in prostate cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e7aa25730939461e8ebe506e7b821266
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