ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer

Abstract The infiltration degree of immune and stromal cells has been shown clinically significant in tumor microenvironment (TME). However, the utility of stromal and immune components in Gastric cancer (GC) has not been investigated in detail. In the present study, ESTIMATE and CIBERSORT algorithm...

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Autores principales:	Yangming Hou, Yingjuan Xu, Dequan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7afe3020f2e4367a7960ec51de1aacf
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spelling	oai:doaj.org-article:e7afe3020f2e4367a7960ec51de1aacf2021-12-02T15:00:55ZADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer10.1038/s41598-021-90330-32045-2322https://doaj.org/article/e7afe3020f2e4367a7960ec51de1aacf2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90330-3https://doaj.org/toc/2045-2322Abstract The infiltration degree of immune and stromal cells has been shown clinically significant in tumor microenvironment (TME). However, the utility of stromal and immune components in Gastric cancer (GC) has not been investigated in detail. In the present study, ESTIMATE and CIBERSORT algorithms were applied to calculate the immune/stromal scores and the proportion of tumor-infiltrating immune cell (TIC) in GC cohort, including 415 cases from The Cancer Genome Atlas (TCGA) database. The differentially expressed genes (DEGs) were screened by Cox proportional hazard regression analysis and protein–protein interaction (PPI) network construction. Then ADAMTS12 was regarded as one of the most predictive factors. Further analysis showed that ADAMTS12 expression was significantly higher in tumor samples and correlated with poor prognosis. Gene Set Enrichment Analysis (GSEA) indicated that in high ADAMTS12 expression group gene sets were mainly enriched in cancer and immune-related activities. In the low ADAMTS12 expression group, the genes were enriched in the oxidative phosphorylation pathway. CIBERSORT analysis for the proportion of TICs revealed that ADAMTS12 expression was positively correlated with Macrophages M0/M1/M2 and negatively correlated with T cells follicular helper. Therefore, ADAMTS12 might be a tumor promoter and responsible for TME status and tumor energy metabolic conversion.Yangming HouYingjuan XuDequan WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yangming Hou Yingjuan Xu Dequan Wu ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
description	Abstract The infiltration degree of immune and stromal cells has been shown clinically significant in tumor microenvironment (TME). However, the utility of stromal and immune components in Gastric cancer (GC) has not been investigated in detail. In the present study, ESTIMATE and CIBERSORT algorithms were applied to calculate the immune/stromal scores and the proportion of tumor-infiltrating immune cell (TIC) in GC cohort, including 415 cases from The Cancer Genome Atlas (TCGA) database. The differentially expressed genes (DEGs) were screened by Cox proportional hazard regression analysis and protein–protein interaction (PPI) network construction. Then ADAMTS12 was regarded as one of the most predictive factors. Further analysis showed that ADAMTS12 expression was significantly higher in tumor samples and correlated with poor prognosis. Gene Set Enrichment Analysis (GSEA) indicated that in high ADAMTS12 expression group gene sets were mainly enriched in cancer and immune-related activities. In the low ADAMTS12 expression group, the genes were enriched in the oxidative phosphorylation pathway. CIBERSORT analysis for the proportion of TICs revealed that ADAMTS12 expression was positively correlated with Macrophages M0/M1/M2 and negatively correlated with T cells follicular helper. Therefore, ADAMTS12 might be a tumor promoter and responsible for TME status and tumor energy metabolic conversion.
format	article
author	Yangming Hou Yingjuan Xu Dequan Wu
author_facet	Yangming Hou Yingjuan Xu Dequan Wu
author_sort	Yangming Hou
title	ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
title_short	ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
title_full	ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
title_fullStr	ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
title_full_unstemmed	ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
title_sort	adamts12 acts as a tumor microenvironment related cancer promoter in gastric cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7afe3020f2e4367a7960ec51de1aacf
work_keys_str_mv	AT yangminghou adamts12actsasatumormicroenvironmentrelatedcancerpromoteringastriccancer AT yingjuanxu adamts12actsasatumormicroenvironmentrelatedcancerpromoteringastriccancer AT dequanwu adamts12actsasatumormicroenvironmentrelatedcancerpromoteringastriccancer
_version_	1718389171051036672

ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer

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