PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy

Significant efforts on the design and development of advanced drug delivery systems for targeted cancer chemotherapy continue to be a major challenge. Here, we reported a kind of reduction-responsive PEGylated doxorubicin (DOX) prodrug via the simple esterification and amidation reactions, which sel...

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Autores principales:	Dongdong Wang, Xiaoyi Zhang, Bingbing Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	reduction-sensitive micelles disulfide biocompatible drug delivery Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/e7b0c676ecf44e49ba14208a50884a3b
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spelling	oai:doaj.org-article:e7b0c676ecf44e49ba14208a50884a3b2021-11-19T07:14:52ZPEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy2296-418510.3389/fbioe.2021.781982https://doaj.org/article/e7b0c676ecf44e49ba14208a50884a3b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.781982/fullhttps://doaj.org/toc/2296-4185Significant efforts on the design and development of advanced drug delivery systems for targeted cancer chemotherapy continue to be a major challenge. Here, we reported a kind of reduction-responsive PEGylated doxorubicin (DOX) prodrug via the simple esterification and amidation reactions, which self-assembled into the biodegradable micelles in solutions. Since there was an obvious difference in the reduction potentials between the oxidizing extracellular milieu and the reducing intracellular fluids, these PEG–disulfide–DOX micelles were localized intracellularly and degraded rapidly by the stimulus to release the drugs once reaching the targeted tumors, which obviously enhanced the therapeutic efficacy with low side effects. Moreover, these reduction-sensitive micelles could also physically encapsulate the free DOX drug into the polymeric cargo, exhibiting a two-phase programmed drug release behavior. Consequently, it showed a potential to develop an intelligent and multifunctional chemotherapeutic payload transporter for the effective tumor therapy.Dongdong WangDongdong WangXiaoyi ZhangBingbing XuBingbing XuFrontiers Media S.A.articlereduction-sensitivemicellesdisulfidebiocompatibledrug deliveryBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reduction-sensitive micelles disulfide biocompatible drug delivery Biotechnology TP248.13-248.65
spellingShingle	reduction-sensitive micelles disulfide biocompatible drug delivery Biotechnology TP248.13-248.65 Dongdong Wang Dongdong Wang Xiaoyi Zhang Bingbing Xu Bingbing Xu PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
description	Significant efforts on the design and development of advanced drug delivery systems for targeted cancer chemotherapy continue to be a major challenge. Here, we reported a kind of reduction-responsive PEGylated doxorubicin (DOX) prodrug via the simple esterification and amidation reactions, which self-assembled into the biodegradable micelles in solutions. Since there was an obvious difference in the reduction potentials between the oxidizing extracellular milieu and the reducing intracellular fluids, these PEG–disulfide–DOX micelles were localized intracellularly and degraded rapidly by the stimulus to release the drugs once reaching the targeted tumors, which obviously enhanced the therapeutic efficacy with low side effects. Moreover, these reduction-sensitive micelles could also physically encapsulate the free DOX drug into the polymeric cargo, exhibiting a two-phase programmed drug release behavior. Consequently, it showed a potential to develop an intelligent and multifunctional chemotherapeutic payload transporter for the effective tumor therapy.
format	article
author	Dongdong Wang Dongdong Wang Xiaoyi Zhang Bingbing Xu Bingbing Xu
author_facet	Dongdong Wang Dongdong Wang Xiaoyi Zhang Bingbing Xu Bingbing Xu
author_sort	Dongdong Wang
title	PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
title_short	PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
title_full	PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
title_fullStr	PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
title_full_unstemmed	PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy
title_sort	pegylated doxorubicin prodrug-forming reduction-sensitive micelles with high drug loading and improved anticancer therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e7b0c676ecf44e49ba14208a50884a3b
work_keys_str_mv	AT dongdongwang pegylateddoxorubicinprodrugformingreductionsensitivemicelleswithhighdrugloadingandimprovedanticancertherapy AT dongdongwang pegylateddoxorubicinprodrugformingreductionsensitivemicelleswithhighdrugloadingandimprovedanticancertherapy AT xiaoyizhang pegylateddoxorubicinprodrugformingreductionsensitivemicelleswithhighdrugloadingandimprovedanticancertherapy AT bingbingxu pegylateddoxorubicinprodrugformingreductionsensitivemicelleswithhighdrugloadingandimprovedanticancertherapy AT bingbingxu pegylateddoxorubicinprodrugformingreductionsensitivemicelleswithhighdrugloadingandimprovedanticancertherapy
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PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy

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