TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila

The hypoxia response pathway couples oxygen availability to physiological adaptations. Using the model system Drosophila melanogaster, here the authors show that hypoxia inhibits TORC1 signalling and increases lipid levels in the larval fat body and that these effects are required for development to...

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Autores principales:	Byoungchun Lee, Elizabeth C. Barretto, Savraj S. Grewal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7b4537cfabe4e899b52a57cb5978599
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spelling	oai:doaj.org-article:e7b4537cfabe4e899b52a57cb59785992021-12-02T17:32:09ZTORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila10.1038/s41467-019-09643-72041-1723https://doaj.org/article/e7b4537cfabe4e899b52a57cb59785992019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09643-7https://doaj.org/toc/2041-1723The hypoxia response pathway couples oxygen availability to physiological adaptations. Using the model system Drosophila melanogaster, here the authors show that hypoxia inhibits TORC1 signalling and increases lipid levels in the larval fat body and that these effects are required for development to adulthood.Byoungchun LeeElizabeth C. BarrettoSavraj S. GrewalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Byoungchun Lee Elizabeth C. Barretto Savraj S. Grewal TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
description	The hypoxia response pathway couples oxygen availability to physiological adaptations. Using the model system Drosophila melanogaster, here the authors show that hypoxia inhibits TORC1 signalling and increases lipid levels in the larval fat body and that these effects are required for development to adulthood.
format	article
author	Byoungchun Lee Elizabeth C. Barretto Savraj S. Grewal
author_facet	Byoungchun Lee Elizabeth C. Barretto Savraj S. Grewal
author_sort	Byoungchun Lee
title	TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
title_short	TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
title_full	TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
title_fullStr	TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
title_full_unstemmed	TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila
title_sort	torc1 modulation in adipose tissue is required for organismal adaptation to hypoxia in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e7b4537cfabe4e899b52a57cb5978599
work_keys_str_mv	AT byoungchunlee torc1modulationinadiposetissueisrequiredfororganismaladaptationtohypoxiaindrosophila AT elizabethcbarretto torc1modulationinadiposetissueisrequiredfororganismaladaptationtohypoxiaindrosophila AT savrajsgrewal torc1modulationinadiposetissueisrequiredfororganismaladaptationtohypoxiaindrosophila
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TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila

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