Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial

Abstract Background To investigate whether respectively radial extracoporeal shock wave therapy (rESWT) or a combination of rESWT, celecoxib and eperisone (rESWT + C + E) are superior in reducing pain in patients with chronic nonspecific low back pain (cnsLBP) compared to C + E alone (a standard tre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuejiao Guo, Lin Li, Zhe Yan, Yunze Li, Zhiyou Peng, Yixin Yang, Yanfeng Zhang, Christoph Schmitz, Zhiying Feng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Radial extracorporeal shock wave therapy (rESWT) Celecoxib Eperisone Chronic nonspecific low back pain Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/e7b5c5cf85224eeba8460a0fdff6ed04
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7b5c5cf85224eeba8460a0fdff6ed04
record_format	dspace
spelling	oai:doaj.org-article:e7b5c5cf85224eeba8460a0fdff6ed042021-12-05T12:19:23ZEfficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial10.1186/s13018-021-02848-x1749-799Xhttps://doaj.org/article/e7b5c5cf85224eeba8460a0fdff6ed042021-12-01T00:00:00Zhttps://doi.org/10.1186/s13018-021-02848-xhttps://doaj.org/toc/1749-799XAbstract Background To investigate whether respectively radial extracoporeal shock wave therapy (rESWT) or a combination of rESWT, celecoxib and eperisone (rESWT + C + E) are superior in reducing pain in patients with chronic nonspecific low back pain (cnsLBP) compared to C + E alone (a standard treatment of this condition in China). Methods 140 patients with cnsLBP were randomly allocated to rESWT (n = 47), rESWT + C + E (n = 45) or C + E alone (n = 48) for four weeks between November 2017 and March 2019. Outcome was evaluated using the Pain Self-Efficacy Questionnaire (PSEQ), Numerical Rating Scale (NRS), Oswestry Low Back Pain Disability Questionnaire and Patient Health Questionnaire 9, collected at baseline as well as one week (W1), W2, W3, W4 and W12 after baseline. Results All scores showed a statistically significant improvement over time. The PSEQ and NRS scores showed a significant Time × Treatment effect. Patients treated with rESWT had significantly lower mean NRS values than patients treated with rESWT + C + E at W1 and W3, as well as than patients treated with C + E alone at W3 and W4. No severe adverse events were observed. Conclusions rESWT may not be inferior to respectively rESWT + C + E or C + E alone in reducing pain in patients with cnsLBP. Level of Evidence: Level I, prospective, randomized, active-controlled trial. Trial registration: Clinicaltrials.gov Identifier NCT03337607. Registered November 09, 2017, https://www.clinicaltrials.gov/ct2/show/NCT03337607 . Level of evidence Level I; prospective, randomized, controlled trial.Xuejiao GuoLin LiZhe YanYunze LiZhiyou PengYixin YangYanfeng ZhangChristoph SchmitzZhiying FengBMCarticleRadial extracorporeal shock wave therapy (rESWT)CelecoxibEperisoneChronic nonspecific low back painOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJournal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Radial extracorporeal shock wave therapy (rESWT) Celecoxib Eperisone Chronic nonspecific low back pain Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	Radial extracorporeal shock wave therapy (rESWT) Celecoxib Eperisone Chronic nonspecific low back pain Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Xuejiao Guo Lin Li Zhe Yan Yunze Li Zhiyou Peng Yixin Yang Yanfeng Zhang Christoph Schmitz Zhiying Feng Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
description	Abstract Background To investigate whether respectively radial extracoporeal shock wave therapy (rESWT) or a combination of rESWT, celecoxib and eperisone (rESWT + C + E) are superior in reducing pain in patients with chronic nonspecific low back pain (cnsLBP) compared to C + E alone (a standard treatment of this condition in China). Methods 140 patients with cnsLBP were randomly allocated to rESWT (n = 47), rESWT + C + E (n = 45) or C + E alone (n = 48) for four weeks between November 2017 and March 2019. Outcome was evaluated using the Pain Self-Efficacy Questionnaire (PSEQ), Numerical Rating Scale (NRS), Oswestry Low Back Pain Disability Questionnaire and Patient Health Questionnaire 9, collected at baseline as well as one week (W1), W2, W3, W4 and W12 after baseline. Results All scores showed a statistically significant improvement over time. The PSEQ and NRS scores showed a significant Time × Treatment effect. Patients treated with rESWT had significantly lower mean NRS values than patients treated with rESWT + C + E at W1 and W3, as well as than patients treated with C + E alone at W3 and W4. No severe adverse events were observed. Conclusions rESWT may not be inferior to respectively rESWT + C + E or C + E alone in reducing pain in patients with cnsLBP. Level of Evidence: Level I, prospective, randomized, active-controlled trial. Trial registration: Clinicaltrials.gov Identifier NCT03337607. Registered November 09, 2017, https://www.clinicaltrials.gov/ct2/show/NCT03337607 . Level of evidence Level I; prospective, randomized, controlled trial.
format	article
author	Xuejiao Guo Lin Li Zhe Yan Yunze Li Zhiyou Peng Yixin Yang Yanfeng Zhang Christoph Schmitz Zhiying Feng
author_facet	Xuejiao Guo Lin Li Zhe Yan Yunze Li Zhiyou Peng Yixin Yang Yanfeng Zhang Christoph Schmitz Zhiying Feng
author_sort	Xuejiao Guo
title	Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
title_short	Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
title_full	Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
title_fullStr	Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
title_full_unstemmed	Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial
title_sort	efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (reswt), reswt combined with celecoxib and eperisone (c + e) or c + e alone: a prospective, randomized trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e7b5c5cf85224eeba8460a0fdff6ed04
work_keys_str_mv	AT xuejiaoguo efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT linli efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT zheyan efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT yunzeli efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT zhiyoupeng efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT yixinyang efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT yanfengzhang efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT christophschmitz efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial AT zhiyingfeng efficacyandsafetyoftreatingchronicnonspecificlowbackpainwithradialextracorporealshockwavetherapyreswtreswtcombinedwithcelecoxibandeperisoneceorcealoneaprospectiverandomizedtrial
_version_	1718372049117773824

Efficacy and safety of treating chronic nonspecific low back pain with radial extracorporeal shock wave therapy (rESWT), rESWT combined with celecoxib and eperisone (C + E) or C + E alone: a prospective, randomized trial

Ejemplares similares