Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.

Chronic kidney disease (CKD) is a significant health challenge associated with high cardiovascular mortality risk. Historically, cardiovascular mortality risk has been found to higher in men than women in the general population. However, recent research has highlighted that this risk may be similar...

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Autores principales:	Sultana Shajahan, Janaki Amin, Jacqueline K Phillips, Cara M Hildreth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7b5e040da284eca984c1743d185af5f
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spelling	oai:doaj.org-article:e7b5e040da284eca984c1743d185af5f2021-12-02T20:15:27ZRelationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0254554https://doaj.org/article/e7b5e040da284eca984c1743d185af5f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254554https://doaj.org/toc/1932-6203Chronic kidney disease (CKD) is a significant health challenge associated with high cardiovascular mortality risk. Historically, cardiovascular mortality risk has been found to higher in men than women in the general population. However, recent research has highlighted that this risk may be similar or even higher in women than men in the CKD population. To address the inconclusive and inconsistent evidence regarding this relationship between sex and cardiovascular mortality within CKD patients, a systematic review and meta-analysis of articles published between January 2004 and October 2020 using PubMed/Medline, EMBASE, Scopus and Cochrane databases was performed. Forty-eight studies were included that reported cardiovascular mortality among adult men relative to women with 95% confidence intervals (CI) or provided sufficient data to calculate risk estimates (RE). Random effects meta-analysis of reported and calculated estimates revealed that male sex was associated with elevated cardiovascular mortality in CKD patients (RE 1.13, CI 1.03-1.25). Subsequent subgroup analyses indicated higher risk in men in studies based in the USA and in men receiving haemodialysis or with non-dialysis-dependent CKD. Though men showed overall higher cardiovascular mortality risk than women, the increased risk was marginal, and appropriate risk awareness is necessary for both sexes with CKD. Further research is needed to understand the impact of treatment modality and geographical distribution on sex differences in cardiovascular mortality in CKD.Sultana ShajahanJanaki AminJacqueline K PhillipsCara M HildrethPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sultana Shajahan Janaki Amin Jacqueline K Phillips Cara M Hildreth Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
description	Chronic kidney disease (CKD) is a significant health challenge associated with high cardiovascular mortality risk. Historically, cardiovascular mortality risk has been found to higher in men than women in the general population. However, recent research has highlighted that this risk may be similar or even higher in women than men in the CKD population. To address the inconclusive and inconsistent evidence regarding this relationship between sex and cardiovascular mortality within CKD patients, a systematic review and meta-analysis of articles published between January 2004 and October 2020 using PubMed/Medline, EMBASE, Scopus and Cochrane databases was performed. Forty-eight studies were included that reported cardiovascular mortality among adult men relative to women with 95% confidence intervals (CI) or provided sufficient data to calculate risk estimates (RE). Random effects meta-analysis of reported and calculated estimates revealed that male sex was associated with elevated cardiovascular mortality in CKD patients (RE 1.13, CI 1.03-1.25). Subsequent subgroup analyses indicated higher risk in men in studies based in the USA and in men receiving haemodialysis or with non-dialysis-dependent CKD. Though men showed overall higher cardiovascular mortality risk than women, the increased risk was marginal, and appropriate risk awareness is necessary for both sexes with CKD. Further research is needed to understand the impact of treatment modality and geographical distribution on sex differences in cardiovascular mortality in CKD.
format	article
author	Sultana Shajahan Janaki Amin Jacqueline K Phillips Cara M Hildreth
author_facet	Sultana Shajahan Janaki Amin Jacqueline K Phillips Cara M Hildreth
author_sort	Sultana Shajahan
title	Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
title_short	Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
title_full	Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
title_fullStr	Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
title_full_unstemmed	Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.
title_sort	relationship between sex and cardiovascular mortality in chronic kidney disease: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e7b5e040da284eca984c1743d185af5f
work_keys_str_mv	AT sultanashajahan relationshipbetweensexandcardiovascularmortalityinchronickidneydiseaseasystematicreviewandmetaanalysis AT janakiamin relationshipbetweensexandcardiovascularmortalityinchronickidneydiseaseasystematicreviewandmetaanalysis AT jacquelinekphillips relationshipbetweensexandcardiovascularmortalityinchronickidneydiseaseasystematicreviewandmetaanalysis AT caramhildreth relationshipbetweensexandcardiovascularmortalityinchronickidneydiseaseasystematicreviewandmetaanalysis
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Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.

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