Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study

The association between eosinophilic esophagitis and celiac disease is still controversial and its prevalence is highly variable. We aimed to investigate the prevalence of esophageal eosinophilia and eosinophilic esophagitis in a large group of children with celiac disease, prospectively followed ov...

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Autores principales:	Fernanda Cristofori, Fulvio Salvatore D’Abramo, Vincenzo Rutigliano, Vanessa Nadia Dargenio, Stefania Castellaneta, Domenico Piscitelli, Davide De Benedittis, Flavia Indrio, Lidia Celeste Raguseo, Michele Barone, Ruggiero Francavilla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	celiac disease esophageal eosinophilia eosinophilic esophagitis eosinophilic gastrointestinal disorders Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e7b5fe56fdce47ebb4dcbbd54a2d8f15
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spelling	oai:doaj.org-article:e7b5fe56fdce47ebb4dcbbd54a2d8f152021-11-25T18:33:47ZEsophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study10.3390/nu131137552072-6643https://doaj.org/article/e7b5fe56fdce47ebb4dcbbd54a2d8f152021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3755https://doaj.org/toc/2072-6643The association between eosinophilic esophagitis and celiac disease is still controversial and its prevalence is highly variable. We aimed to investigate the prevalence of esophageal eosinophilia and eosinophilic esophagitis in a large group of children with celiac disease, prospectively followed over 11 years. Methods: Prospective observational study performed between 2008 and 2019. Celiac disease diagnosis was based on ESPGHAN criteria. At least four esophageal biopsies were sampled in patients who underwent endoscopy. The presence of at least 15 eosinophils/HPF on esophageal biopsies was considered suggestive of esophageal eosinophilia; at the same time, eosinophilic esophagitis was diagnosed according to the International Consensus Diagnostic Criteria for Eosinophilic Esophagitis. Results: A total of 465 children (M 42% mean age 7.1 years (range: 1–16)) were diagnosed with celiac disease. Three hundred and seventy patients underwent endoscopy, and esophageal biopsies were available in 313. The prevalence of esophageal eosinophilia in children with celiac disease was 1.6% (95% CI: 0.54–2.9%). Only one child was diagnosed as eosinophilic esophagitis; we calculated a prevalence of 0.3% (95% CI: 0.2–0.5%). The odds ratio for an association between eosinophilic esophagitis and celiac disease was at least 6.5 times higher (95% CI: 0.89–47.7%; <i>p</i> = 0.06) than in the general population. Conclusion: The finding of an increased number of eosinophils (>15/HPF) in celiac patients does not have a clinical implication or warrant intervention, and therefore we do not recommend routine esophageal biopsies unless clinically indicated.Fernanda CristoforiFulvio Salvatore D’AbramoVincenzo RutiglianoVanessa Nadia DargenioStefania CastellanetaDomenico PiscitelliDavide De BenedittisFlavia IndrioLidia Celeste RaguseoMichele BaroneRuggiero FrancavillaMDPI AGarticleceliac diseaseesophageal eosinophiliaeosinophilic esophagitiseosinophilic gastrointestinal disordersNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3755, p 3755 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	celiac disease esophageal eosinophilia eosinophilic esophagitis eosinophilic gastrointestinal disorders Nutrition. Foods and food supply TX341-641
spellingShingle	celiac disease esophageal eosinophilia eosinophilic esophagitis eosinophilic gastrointestinal disorders Nutrition. Foods and food supply TX341-641 Fernanda Cristofori Fulvio Salvatore D’Abramo Vincenzo Rutigliano Vanessa Nadia Dargenio Stefania Castellaneta Domenico Piscitelli Davide De Benedittis Flavia Indrio Lidia Celeste Raguseo Michele Barone Ruggiero Francavilla Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
description	The association between eosinophilic esophagitis and celiac disease is still controversial and its prevalence is highly variable. We aimed to investigate the prevalence of esophageal eosinophilia and eosinophilic esophagitis in a large group of children with celiac disease, prospectively followed over 11 years. Methods: Prospective observational study performed between 2008 and 2019. Celiac disease diagnosis was based on ESPGHAN criteria. At least four esophageal biopsies were sampled in patients who underwent endoscopy. The presence of at least 15 eosinophils/HPF on esophageal biopsies was considered suggestive of esophageal eosinophilia; at the same time, eosinophilic esophagitis was diagnosed according to the International Consensus Diagnostic Criteria for Eosinophilic Esophagitis. Results: A total of 465 children (M 42% mean age 7.1 years (range: 1–16)) were diagnosed with celiac disease. Three hundred and seventy patients underwent endoscopy, and esophageal biopsies were available in 313. The prevalence of esophageal eosinophilia in children with celiac disease was 1.6% (95% CI: 0.54–2.9%). Only one child was diagnosed as eosinophilic esophagitis; we calculated a prevalence of 0.3% (95% CI: 0.2–0.5%). The odds ratio for an association between eosinophilic esophagitis and celiac disease was at least 6.5 times higher (95% CI: 0.89–47.7%; <i>p</i> = 0.06) than in the general population. Conclusion: The finding of an increased number of eosinophils (>15/HPF) in celiac patients does not have a clinical implication or warrant intervention, and therefore we do not recommend routine esophageal biopsies unless clinically indicated.
format	article
author	Fernanda Cristofori Fulvio Salvatore D’Abramo Vincenzo Rutigliano Vanessa Nadia Dargenio Stefania Castellaneta Domenico Piscitelli Davide De Benedittis Flavia Indrio Lidia Celeste Raguseo Michele Barone Ruggiero Francavilla
author_facet	Fernanda Cristofori Fulvio Salvatore D’Abramo Vincenzo Rutigliano Vanessa Nadia Dargenio Stefania Castellaneta Domenico Piscitelli Davide De Benedittis Flavia Indrio Lidia Celeste Raguseo Michele Barone Ruggiero Francavilla
author_sort	Fernanda Cristofori
title	Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
title_short	Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
title_full	Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
title_fullStr	Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
title_full_unstemmed	Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study
title_sort	esophageal eosinophilia and eosinophilic esophagitis in celiac children: a ten year prospective observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e7b5fe56fdce47ebb4dcbbd54a2d8f15
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Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study

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