Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance

Here, the authors discover that NGF, upregulated by transcription factor ZBTB46 in prostate cancer exposed to androgen therapy, promotes neuroendocrine differentiation. They show that NGF interacts with the GPCR CHRM4, that both NGF and CHRM4 are upregulated in highly metastatic prostate cancer and...

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Autores principales:	Wei-Yu Chen, Yu-Ching Wen, Shian-Ren Lin, Hsiu-Lien Yeh, Kuo-Ching Jiang, Wei-Hao Chen, Yow-Sien Lin, Qingfu Zhang, Phui-Ly Liew, Michael Hsiao, Jiaoti Huang, Yen-Nien Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e7b7c66702104de49414ef8b54df1488
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spelling	oai:doaj.org-article:e7b7c66702104de49414ef8b54df14882021-12-02T15:07:31ZNerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance10.1038/s42003-020-01549-12399-3642https://doaj.org/article/e7b7c66702104de49414ef8b54df14882021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01549-1https://doaj.org/toc/2399-3642Here, the authors discover that NGF, upregulated by transcription factor ZBTB46 in prostate cancer exposed to androgen therapy, promotes neuroendocrine differentiation. They show that NGF interacts with the GPCR CHRM4, that both NGF and CHRM4 are upregulated in highly metastatic prostate cancer and that targeting NGF reduces therapy resistance in a mouse xenograft model.Wei-Yu ChenYu-Ching WenShian-Ren LinHsiu-Lien YehKuo-Ching JiangWei-Hao ChenYow-Sien LinQingfu ZhangPhui-Ly LiewMichael HsiaoJiaoti HuangYen-Nien LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Wei-Yu Chen Yu-Ching Wen Shian-Ren Lin Hsiu-Lien Yeh Kuo-Ching Jiang Wei-Hao Chen Yow-Sien Lin Qingfu Zhang Phui-Ly Liew Michael Hsiao Jiaoti Huang Yen-Nien Liu Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
description	Here, the authors discover that NGF, upregulated by transcription factor ZBTB46 in prostate cancer exposed to androgen therapy, promotes neuroendocrine differentiation. They show that NGF interacts with the GPCR CHRM4, that both NGF and CHRM4 are upregulated in highly metastatic prostate cancer and that targeting NGF reduces therapy resistance in a mouse xenograft model.
format	article
author	Wei-Yu Chen Yu-Ching Wen Shian-Ren Lin Hsiu-Lien Yeh Kuo-Ching Jiang Wei-Hao Chen Yow-Sien Lin Qingfu Zhang Phui-Ly Liew Michael Hsiao Jiaoti Huang Yen-Nien Liu
author_facet	Wei-Yu Chen Yu-Ching Wen Shian-Ren Lin Hsiu-Lien Yeh Kuo-Ching Jiang Wei-Hao Chen Yow-Sien Lin Qingfu Zhang Phui-Ly Liew Michael Hsiao Jiaoti Huang Yen-Nien Liu
author_sort	Wei-Yu Chen
title	Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
title_short	Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
title_full	Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
title_fullStr	Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
title_full_unstemmed	Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
title_sort	nerve growth factor interacts with chrm4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7b7c66702104de49414ef8b54df1488
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Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance

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