A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction

Omar Yaxmehen Bello-Chavolla,1,2 Arsenio Vargas-Vázquez,1,3,* Neftali Eduardo Antonio-Villa,1,3,* Fabiola Mabel Del Razo-Olvera,1 Daniel Elías-López,1 Carlos A Aguilar-Salinas1,4,5 For the Metabolic Syndrome Study Group1Unidad de Investigación de Enfermeda...

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Autores principales:	Bello-Chavolla OY, Vargas-Vázquez A, Antonio-Villa NE, Del Razo-Olvera FM, Elías-López D, Aguilar-Salinas CA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	metabolic syndrome obesity incidence mexicans metabolic risk Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e7be290a656d4e46a758276e1d6a32ff
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spelling	oai:doaj.org-article:e7be290a656d4e46a758276e1d6a32ff2021-12-02T14:20:31ZA High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction1178-7007https://doaj.org/article/e7be290a656d4e46a758276e1d6a32ff2021-03-01T00:00:00Zhttps://www.dovepress.com/a-high-incidence-of-metabolic-syndrome-traits-in-mexicans-points-at-ob-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Omar Yaxmehen Bello-Chavolla,1,2 Arsenio Vargas-Vázquez,1,3,* Neftali Eduardo Antonio-Villa,1,3,* Fabiola Mabel Del Razo-Olvera,1 Daniel Elías-López,1 Carlos A Aguilar-Salinas1,4,5 For the Metabolic Syndrome Study Group1Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2Division of Research, Instituto Nacional de Geriatría, Mexico City, Mexico; 3MD/PhD (PECEM) Program, Facultad de Medicina, UNAM, Mexico City, Mexico; 4Division of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 5Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico*These authors contributed equally to this workCorrespondence: Carlos A Aguilar-SalinasUnidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Distrito Federal, CP 14080, MéxicoTel +525554870900, 5703Email caguilarsalinas@yahoo.comIntroduction: Metabolic Syndrome (MS) is a construct relating to a series of metabolic dysfunctions attributable to insulin resistance and obesity. Here, we estimate the incidence of MS according to their individual components using a Mexican open-population cohort.Methods: We evaluated data of 6144 Mexicans amongst whom 3340 did not have MS either by IDF or ATP-III definitions using data from an open-population cohort. We estimated the incidence of MS and each of its traits after a median follow-up of 2.24 (IQR 2.05– 2.58) years and evaluated risk factors for MS incidence and each of its traits. We also explored individuals without any MS trait to evaluate trait and MS incidence after follow-up.Results: We observed a high incidence of MS-IDF (115.11 cases per 1000 person-years, 95% CI 107.76– 122.47), followed by MS-ATP-III (75.77 cases per 1000 person-years, 95% CI). The MS traits with the highest incidence were low HDL-C and abdominal obesity, which was consistent for subjects without MS and those without any MS trait. When assessing predictors of MS incidence, obesity, insulin resistance, and increased apolipoprotein B levels predicted MS incidence. Weight loss > 5% of body weight and physical activity were the main protective factors. Obesity was a main determinant for incident MS traits in our population, with weight loss being also a protective factor for most MS traits.Conclusion: We observed a high incidence of MS in apparently healthy Mexican adults. Low HDL-C and abdominal obesity were the most frequent incident MS traits, with obesity being the main determinant of its incidence.Keywords: metabolic syndrome, obesity, incidence, Mexicans, metabolic riskBello-Chavolla OYVargas-Vázquez AAntonio-Villa NEDel Razo-Olvera FMElías-López DAguilar-Salinas CADove Medical Pressarticlemetabolic syndromeobesityincidencemexicansmetabolic riskSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1073-1082 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome obesity incidence mexicans metabolic risk Specialties of internal medicine RC581-951
spellingShingle	metabolic syndrome obesity incidence mexicans metabolic risk Specialties of internal medicine RC581-951 Bello-Chavolla OY Vargas-Vázquez A Antonio-Villa NE Del Razo-Olvera FM Elías-López D Aguilar-Salinas CA A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
description	Omar Yaxmehen Bello-Chavolla,1,2 Arsenio Vargas-Vázquez,1,3,* Neftali Eduardo Antonio-Villa,1,3,* Fabiola Mabel Del Razo-Olvera,1 Daniel Elías-López,1 Carlos A Aguilar-Salinas1,4,5 For the Metabolic Syndrome Study Group1Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2Division of Research, Instituto Nacional de Geriatría, Mexico City, Mexico; 3MD/PhD (PECEM) Program, Facultad de Medicina, UNAM, Mexico City, Mexico; 4Division of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 5Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico*These authors contributed equally to this workCorrespondence: Carlos A Aguilar-SalinasUnidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Distrito Federal, CP 14080, MéxicoTel +525554870900, 5703Email caguilarsalinas@yahoo.comIntroduction: Metabolic Syndrome (MS) is a construct relating to a series of metabolic dysfunctions attributable to insulin resistance and obesity. Here, we estimate the incidence of MS according to their individual components using a Mexican open-population cohort.Methods: We evaluated data of 6144 Mexicans amongst whom 3340 did not have MS either by IDF or ATP-III definitions using data from an open-population cohort. We estimated the incidence of MS and each of its traits after a median follow-up of 2.24 (IQR 2.05– 2.58) years and evaluated risk factors for MS incidence and each of its traits. We also explored individuals without any MS trait to evaluate trait and MS incidence after follow-up.Results: We observed a high incidence of MS-IDF (115.11 cases per 1000 person-years, 95% CI 107.76– 122.47), followed by MS-ATP-III (75.77 cases per 1000 person-years, 95% CI). The MS traits with the highest incidence were low HDL-C and abdominal obesity, which was consistent for subjects without MS and those without any MS trait. When assessing predictors of MS incidence, obesity, insulin resistance, and increased apolipoprotein B levels predicted MS incidence. Weight loss > 5% of body weight and physical activity were the main protective factors. Obesity was a main determinant for incident MS traits in our population, with weight loss being also a protective factor for most MS traits.Conclusion: We observed a high incidence of MS in apparently healthy Mexican adults. Low HDL-C and abdominal obesity were the most frequent incident MS traits, with obesity being the main determinant of its incidence.Keywords: metabolic syndrome, obesity, incidence, Mexicans, metabolic risk
format	article
author	Bello-Chavolla OY Vargas-Vázquez A Antonio-Villa NE Del Razo-Olvera FM Elías-López D Aguilar-Salinas CA
author_facet	Bello-Chavolla OY Vargas-Vázquez A Antonio-Villa NE Del Razo-Olvera FM Elías-López D Aguilar-Salinas CA
author_sort	Bello-Chavolla OY
title	A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
title_short	A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
title_full	A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
title_fullStr	A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
title_full_unstemmed	A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction
title_sort	high incidence of metabolic syndrome traits in mexicans points at obesity-related metabolic dysfunction
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e7be290a656d4e46a758276e1d6a32ff
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A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction

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