Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity

The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum...

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Autores principales:	El-Sayed, E. I., Mossad, W.G., Hassanin A. I., Shabana, W.
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	fmd vaccine immune response montanide isa201 montanide isa206 aluminum hydroxide gel Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.98318 https://doaj.org/article/e7c361c2bfa445f89155595d963322a5
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spelling	oai:doaj.org-article:e7c361c2bfa445f89155595d963322a52021-12-02T11:43:58ZImmunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicityhttps://dx.doi.org/10.21608/javs.2020.983181687-40722090-3308https://doaj.org/article/e7c361c2bfa445f89155595d963322a52020-07-01T00:00:00Zhttps://javs.journals.ekb.eg/article_98318.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum hydroxide gel effect with the use of oil adjuvants on the immune response of polyvalent foot and mouth disease (FMD) vaccine in sheep. Twenty five sheep, were divided to five group (five animals/group) where the 1st group was vaccinated with polyvalent FMD ISA 206 oil vaccine, 2nd group was vaccinated with polyvalent FMD ISA 206 + aluminum hydroxide gel vaccine, 3rd group was vaccinated with polyvalent ISA 201 oil vaccine, 4th group was vaccinated with polyvalent ISA 201 + aluminum hydroxide gel vaccine, 5th group was kept as a negative control (non-vaccinated). Blood and Serum samples were collected from vaccinated animals for monitoring the cellular and humeral immune responses. The results showed that sheep groups immunized with the vaccine prepared with ISA 201with aluminum hydroxide gel is considered the best cellular and humeral immunity post vaccinal response then ISA 201 followed by ISA 206 with aluminum hydroxide gel and the last one is the vaccine prepared with ISA 206 alone.It can be concluded that, ISA oils with aluminum hydroxide gel induce the best cellular and humeral immunity.El-Sayed, E. I. Mossad, W.G.Hassanin A. I. Shabana, W.Egyptian Society for Animal Managementarticlefmd vaccineimmune responsemontanide isa201montanide isa206aluminum hydroxide gelZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 3, Pp 14-30 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	fmd vaccine immune response montanide isa201 montanide isa206 aluminum hydroxide gel Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	fmd vaccine immune response montanide isa201 montanide isa206 aluminum hydroxide gel Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 El-Sayed, E. I. Mossad, W.G. Hassanin A. I. Shabana, W. Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
description	The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum hydroxide gel effect with the use of oil adjuvants on the immune response of polyvalent foot and mouth disease (FMD) vaccine in sheep. Twenty five sheep, were divided to five group (five animals/group) where the 1st group was vaccinated with polyvalent FMD ISA 206 oil vaccine, 2nd group was vaccinated with polyvalent FMD ISA 206 + aluminum hydroxide gel vaccine, 3rd group was vaccinated with polyvalent ISA 201 oil vaccine, 4th group was vaccinated with polyvalent ISA 201 + aluminum hydroxide gel vaccine, 5th group was kept as a negative control (non-vaccinated). Blood and Serum samples were collected from vaccinated animals for monitoring the cellular and humeral immune responses. The results showed that sheep groups immunized with the vaccine prepared with ISA 201with aluminum hydroxide gel is considered the best cellular and humeral immunity post vaccinal response then ISA 201 followed by ISA 206 with aluminum hydroxide gel and the last one is the vaccine prepared with ISA 206 alone.It can be concluded that, ISA oils with aluminum hydroxide gel induce the best cellular and humeral immunity.
format	article
author	El-Sayed, E. I. Mossad, W.G. Hassanin A. I. Shabana, W.
author_facet	El-Sayed, E. I. Mossad, W.G. Hassanin A. I. Shabana, W.
author_sort	El-Sayed, E. I.
title	Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
title_short	Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
title_full	Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
title_fullStr	Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
title_full_unstemmed	Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
title_sort	immunomodulating efficacy of different adjuvants in formulation of foot and mouth disease vaccine relative to its immunogenicity
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.98318 https://doaj.org/article/e7c361c2bfa445f89155595d963322a5
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Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity

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