Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery

Background: In recent decades, improvement in sensory and motor function after spinal cord injury (SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in the regeneration of central nervous system injuries. Methods: We assessed the effectiveness of autologous...

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Autores principales:	Maryam Golmohammadi, Mohammadhosein Akhlaghpasand, Saeed Oraee-Yazdani, Alireza Zali
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2020
Materias:	schwann cell bone marrow mesenchymal stem cell spinal cord injury sensory recovery Medicine R
Acceso en línea:	https://doaj.org/article/e7c3723303034a21a86d7cdb51241c06
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spelling	oai:doaj.org-article:e7c3723303034a21a86d7cdb51241c062021-11-16T10:50:32ZEffectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery2383-18712383-209610.34172/icnj.2021.03https://doaj.org/article/e7c3723303034a21a86d7cdb51241c062020-12-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/33110/26384https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096Background: In recent decades, improvement in sensory and motor function after spinal cord injury (SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in the regeneration of central nervous system injuries. Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derived mesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. Five patients with a mean ± SD age of 38.80 ± 5.84 years were enrolled in the study. The follow-up course was 12 months. Results: We found sensory changes in two patients assessed by the American Spinal Injury Association’s (ASIA’s) impairment scale. Systemic complications were not observed during the course of the study. Conclusion: There were no adverse finding after cell transplantation. Also we observed improvement in sensory score in two patients. It seems that the use of this combination of cell therapy may be effective; but large group studies with control group are required to clarify the effect of either cells.Maryam GolmohammadiMohammadhosein AkhlaghpasandSaeed Oraee-YazdaniAlireza ZaliShahid Beheshti University of Medical Sciencesarticleschwann cellbone marrowmesenchymal stem cellspinal cord injurysensory recoveryMedicineRENInternational Clinical Neuroscience Journal, Vol 8, Iss 1, Pp 10-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	schwann cell bone marrow mesenchymal stem cell spinal cord injury sensory recovery Medicine R
spellingShingle	schwann cell bone marrow mesenchymal stem cell spinal cord injury sensory recovery Medicine R Maryam Golmohammadi Mohammadhosein Akhlaghpasand Saeed Oraee-Yazdani Alireza Zali Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
description	Background: In recent decades, improvement in sensory and motor function after spinal cord injury (SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in the regeneration of central nervous system injuries. Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derived mesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. Five patients with a mean ± SD age of 38.80 ± 5.84 years were enrolled in the study. The follow-up course was 12 months. Results: We found sensory changes in two patients assessed by the American Spinal Injury Association’s (ASIA’s) impairment scale. Systemic complications were not observed during the course of the study. Conclusion: There were no adverse finding after cell transplantation. Also we observed improvement in sensory score in two patients. It seems that the use of this combination of cell therapy may be effective; but large group studies with control group are required to clarify the effect of either cells.
format	article
author	Maryam Golmohammadi Mohammadhosein Akhlaghpasand Saeed Oraee-Yazdani Alireza Zali
author_facet	Maryam Golmohammadi Mohammadhosein Akhlaghpasand Saeed Oraee-Yazdani Alireza Zali
author_sort	Maryam Golmohammadi
title	Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
title_short	Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
title_full	Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
title_fullStr	Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
title_full_unstemmed	Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery
title_sort	effectiveness of autologous schwann cell and bone marrow-derived mesenchymal stem cell transplantation for individuals with spinal cord injury in promoting sensory recovery
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/e7c3723303034a21a86d7cdb51241c06
work_keys_str_mv	AT maryamgolmohammadi effectivenessofautologousschwanncellandbonemarrowderivedmesenchymalstemcelltransplantationforindividualswithspinalcordinjuryinpromotingsensoryrecovery AT mohammadhoseinakhlaghpasand effectivenessofautologousschwanncellandbonemarrowderivedmesenchymalstemcelltransplantationforindividualswithspinalcordinjuryinpromotingsensoryrecovery AT saeedoraeeyazdani effectivenessofautologousschwanncellandbonemarrowderivedmesenchymalstemcelltransplantationforindividualswithspinalcordinjuryinpromotingsensoryrecovery AT alirezazali effectivenessofautologousschwanncellandbonemarrowderivedmesenchymalstemcelltransplantationforindividualswithspinalcordinjuryinpromotingsensoryrecovery
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Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery

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