Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.

<h4>Background</h4>Fibrinogen is an important biomarker of inflammation, but findings from longitudinal studies that correlated fibrinogen with lung function in older adults are inconsistent.<h4>Aim</h4>To investigate the relationship between fibrinogen plasma levels and lung...

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Autores principales:	Camila Thais Adam, Ione Jayce Ceola Schneider, Danielle Soares Rocha Vieira, Tauana Prestes Schmidt, Fernando Cesar Wehrmeister, Cesar de Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7c801dda9b84ae5bb0fafecc5cac11f
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spelling	oai:doaj.org-article:e7c801dda9b84ae5bb0fafecc5cac11f2021-12-02T20:05:56ZAre elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.1932-620310.1371/journal.pone.0259498https://doaj.org/article/e7c801dda9b84ae5bb0fafecc5cac11f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259498https://doaj.org/toc/1932-6203<h4>Background</h4>Fibrinogen is an important biomarker of inflammation, but findings from longitudinal studies that correlated fibrinogen with lung function in older adults are inconsistent.<h4>Aim</h4>To investigate the relationship between fibrinogen plasma levels and lung function impairment later in life.<h4>Methods</h4>Longitudinal analysis of 2,150 participants of the English Longitudinal Study of Ageing (ELSA) aged 50 years and older. Associations between changes in plasma fibrinogen between waves 2 (2004-05) and 4 (2008-09) and lung function in wave 6 (2012-13) were performed using multiple linear regression adjusted by potential confounders.<h4>Results</h4>Regarding the fibrinogen profile, 18.5% of the participants presented higher levels in both waves. In the adjusted models, the maintenance of high fibrinogen levels was associated with a significant reduction of lung function only for men. FEV1 showed a reduction of 0.17L, FVC of 0.22L, and the percentages predicted were 5.16% for FEV1 and 6.21% for FVC compared to those that maintained normal levels of fibrinogen.<h4>Discussion</h4>To the best of our knowledge, this was the first study investigating the relationship between changes in fibrinogen levels over a long follow-up period and lung function in older adults without pre-existing chronic diseases. ELSA has information on critical demographic and clinical parameters, which allowed to adjust for potential confounding factors.<h4>Conclusion</h4>It was found that the persistence of high levels of plasma fibrinogen in older English men, but not women, is associated with lung function decline. Therefore, plasma fibrinogen showed to be an important biomarker of pulmonary dysfunction in this population.Camila Thais AdamIone Jayce Ceola SchneiderDanielle Soares Rocha VieiraTauana Prestes SchmidtFernando Cesar WehrmeisterCesar de OliveiraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259498 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camila Thais Adam Ione Jayce Ceola Schneider Danielle Soares Rocha Vieira Tauana Prestes Schmidt Fernando Cesar Wehrmeister Cesar de Oliveira Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
description	<h4>Background</h4>Fibrinogen is an important biomarker of inflammation, but findings from longitudinal studies that correlated fibrinogen with lung function in older adults are inconsistent.<h4>Aim</h4>To investigate the relationship between fibrinogen plasma levels and lung function impairment later in life.<h4>Methods</h4>Longitudinal analysis of 2,150 participants of the English Longitudinal Study of Ageing (ELSA) aged 50 years and older. Associations between changes in plasma fibrinogen between waves 2 (2004-05) and 4 (2008-09) and lung function in wave 6 (2012-13) were performed using multiple linear regression adjusted by potential confounders.<h4>Results</h4>Regarding the fibrinogen profile, 18.5% of the participants presented higher levels in both waves. In the adjusted models, the maintenance of high fibrinogen levels was associated with a significant reduction of lung function only for men. FEV1 showed a reduction of 0.17L, FVC of 0.22L, and the percentages predicted were 5.16% for FEV1 and 6.21% for FVC compared to those that maintained normal levels of fibrinogen.<h4>Discussion</h4>To the best of our knowledge, this was the first study investigating the relationship between changes in fibrinogen levels over a long follow-up period and lung function in older adults without pre-existing chronic diseases. ELSA has information on critical demographic and clinical parameters, which allowed to adjust for potential confounding factors.<h4>Conclusion</h4>It was found that the persistence of high levels of plasma fibrinogen in older English men, but not women, is associated with lung function decline. Therefore, plasma fibrinogen showed to be an important biomarker of pulmonary dysfunction in this population.
format	article
author	Camila Thais Adam Ione Jayce Ceola Schneider Danielle Soares Rocha Vieira Tauana Prestes Schmidt Fernando Cesar Wehrmeister Cesar de Oliveira
author_facet	Camila Thais Adam Ione Jayce Ceola Schneider Danielle Soares Rocha Vieira Tauana Prestes Schmidt Fernando Cesar Wehrmeister Cesar de Oliveira
author_sort	Camila Thais Adam
title	Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
title_short	Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
title_full	Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
title_fullStr	Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
title_full_unstemmed	Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.
title_sort	are elevated plasma fibrinogen associated with lung function? an 8-year follow-up of the elsa study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e7c801dda9b84ae5bb0fafecc5cac11f
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Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.

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