Functional dissection of human targets for KSHV-encoded miRNAs using network analysis

Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease, etc. In this study, we firstly systematically constructed the KSHV-encoded miRNA-regulated co-expressed protein-protein interaction ne...

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Autores principales:	Yu Wang, Yun Lin, Yanzhi Guo, Xuemei Pu, Menglong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7cb883feb0f4ffd8ab3ba2c5985dd33
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spelling	oai:doaj.org-article:e7cb883feb0f4ffd8ab3ba2c5985dd332021-12-02T12:31:54ZFunctional dissection of human targets for KSHV-encoded miRNAs using network analysis10.1038/s41598-017-03462-w2045-2322https://doaj.org/article/e7cb883feb0f4ffd8ab3ba2c5985dd332017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03462-whttps://doaj.org/toc/2045-2322Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease, etc. In this study, we firstly systematically constructed the KSHV-encoded miRNA-regulated co-expressed protein-protein interaction network (CePPIN), which display the biological knowledge regarding the mechanism of miRNA-regulated KSHV pathogenesis. Then, we investigated the topological parameters for the proteins in CePPIN, especially for those miRNA targets and we found that cellular target genes of KSHV-encoded miRNAs tend to be hubs and bottlenecks in the network. Then the GO and KEGG pathway analysis suggests that miRNA targets are involved in various cellular processes mostly related to immune regulate and cell cycle. Enrichment analysis was also performed to identify the six important functional modules which are proven to be highly related to KSHV pathogenesis. Finally, difference analysis of common targets and specific targets shows that two kinds of targets are different in terms of both topological properties and enriched functions, thus we can extrapolate that the functions of KSHV-encoded miRNAs can be also classified into two generic groups, one can act as functional mimics of some oncogenic human miRNAs which contribute to tumorigenesis and the other can contribute to maintaining viral survival.Yu WangYun LinYanzhi GuoXuemei PuMenglong LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Wang Yun Lin Yanzhi Guo Xuemei Pu Menglong Li Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
description	Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease, etc. In this study, we firstly systematically constructed the KSHV-encoded miRNA-regulated co-expressed protein-protein interaction network (CePPIN), which display the biological knowledge regarding the mechanism of miRNA-regulated KSHV pathogenesis. Then, we investigated the topological parameters for the proteins in CePPIN, especially for those miRNA targets and we found that cellular target genes of KSHV-encoded miRNAs tend to be hubs and bottlenecks in the network. Then the GO and KEGG pathway analysis suggests that miRNA targets are involved in various cellular processes mostly related to immune regulate and cell cycle. Enrichment analysis was also performed to identify the six important functional modules which are proven to be highly related to KSHV pathogenesis. Finally, difference analysis of common targets and specific targets shows that two kinds of targets are different in terms of both topological properties and enriched functions, thus we can extrapolate that the functions of KSHV-encoded miRNAs can be also classified into two generic groups, one can act as functional mimics of some oncogenic human miRNAs which contribute to tumorigenesis and the other can contribute to maintaining viral survival.
format	article
author	Yu Wang Yun Lin Yanzhi Guo Xuemei Pu Menglong Li
author_facet	Yu Wang Yun Lin Yanzhi Guo Xuemei Pu Menglong Li
author_sort	Yu Wang
title	Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
title_short	Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
title_full	Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
title_fullStr	Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
title_full_unstemmed	Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
title_sort	functional dissection of human targets for kshv-encoded mirnas using network analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e7cb883feb0f4ffd8ab3ba2c5985dd33
work_keys_str_mv	AT yuwang functionaldissectionofhumantargetsforkshvencodedmirnasusingnetworkanalysis AT yunlin functionaldissectionofhumantargetsforkshvencodedmirnasusingnetworkanalysis AT yanzhiguo functionaldissectionofhumantargetsforkshvencodedmirnasusingnetworkanalysis AT xuemeipu functionaldissectionofhumantargetsforkshvencodedmirnasusingnetworkanalysis AT menglongli functionaldissectionofhumantargetsforkshvencodedmirnasusingnetworkanalysis
_version_	1718394250786242560

Functional dissection of human targets for KSHV-encoded miRNAs using network analysis

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