Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

<h4>Introduction</h4>Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.&...

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Autores principales:	Hao-Tsai Cheng, Chen-June Seak, Chien-Cheng Cheng, Tsung-Hsing Chen, Chang-Mu Sung, Shih-Ching Kang, Yu-Jhou Chen, Chip-Jin Ng, Chao-Wei Lee, Shu-Wei Huang, Hsin-Chih Huang, Tzung-Hai Yen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7cd30867f2444feb8388a9c11fca58e
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spelling	oai:doaj.org-article:e7cd30867f2444feb8388a9c11fca58e2021-12-02T20:12:44ZProfiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.1932-620310.1371/journal.pone.0260012https://doaj.org/article/e7cd30867f2444feb8388a9c11fca58e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260012https://doaj.org/toc/1932-6203<h4>Introduction</h4>Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.<h4>Methods</h4>This prospective, cross-sectional study enrolled 22 patients admitted to Chang Gung Memorial Hospital between March and October 2018. All patients underwent esophagogastroduodenoscopy in 24 hours. Patients were categorized into two subgroups, as mild (<2b, n = 11) or severe (≥2b, n = 11) group.<h4>Results</h4>The neutrophil count was higher in severe than mild group (P = 0.032). Patients in mild and severe groups exhibited significantly higher circulating inflammatory cytokines than healthy control, including interleukin (IL)-2, IL-5, IL-8, IL-9, IL-12, IL-13, interferon-gamma inducible protein-10, macrophage inflammatory protein-1 beta, regulated upon activation, normal T cell expressed and presumably secreted and tumor necrosis factor-alpha. Furthermore, the levels of IL-2 and tumor necrosis factor-alpha were significantly higher in patients with severe group than mild group. Although there was no difference in cumulative survival between both groups (P = 0.147), the severe group received more operations (P = 0.035) and suffered more gastrointestinal complications (P = 0.035) than mild group.<h4>Conclusion</h4>Caustic substance ingestion produces mucosal damages and leads to excessive neutrophils and inflammatory cytokines in peripheral blood.Hao-Tsai ChengChen-June SeakChien-Cheng ChengTsung-Hsing ChenChang-Mu SungShih-Ching KangYu-Jhou ChenChip-Jin NgChao-Wei LeeShu-Wei HuangHsin-Chih HuangTzung-Hai YenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260012 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao-Tsai Cheng Chen-June Seak Chien-Cheng Cheng Tsung-Hsing Chen Chang-Mu Sung Shih-Ching Kang Yu-Jhou Chen Chip-Jin Ng Chao-Wei Lee Shu-Wei Huang Hsin-Chih Huang Tzung-Hai Yen Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
description	<h4>Introduction</h4>Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.<h4>Methods</h4>This prospective, cross-sectional study enrolled 22 patients admitted to Chang Gung Memorial Hospital between March and October 2018. All patients underwent esophagogastroduodenoscopy in 24 hours. Patients were categorized into two subgroups, as mild (<2b, n = 11) or severe (≥2b, n = 11) group.<h4>Results</h4>The neutrophil count was higher in severe than mild group (P = 0.032). Patients in mild and severe groups exhibited significantly higher circulating inflammatory cytokines than healthy control, including interleukin (IL)-2, IL-5, IL-8, IL-9, IL-12, IL-13, interferon-gamma inducible protein-10, macrophage inflammatory protein-1 beta, regulated upon activation, normal T cell expressed and presumably secreted and tumor necrosis factor-alpha. Furthermore, the levels of IL-2 and tumor necrosis factor-alpha were significantly higher in patients with severe group than mild group. Although there was no difference in cumulative survival between both groups (P = 0.147), the severe group received more operations (P = 0.035) and suffered more gastrointestinal complications (P = 0.035) than mild group.<h4>Conclusion</h4>Caustic substance ingestion produces mucosal damages and leads to excessive neutrophils and inflammatory cytokines in peripheral blood.
format	article
author	Hao-Tsai Cheng Chen-June Seak Chien-Cheng Cheng Tsung-Hsing Chen Chang-Mu Sung Shih-Ching Kang Yu-Jhou Chen Chip-Jin Ng Chao-Wei Lee Shu-Wei Huang Hsin-Chih Huang Tzung-Hai Yen
author_facet	Hao-Tsai Cheng Chen-June Seak Chien-Cheng Cheng Tsung-Hsing Chen Chang-Mu Sung Shih-Ching Kang Yu-Jhou Chen Chip-Jin Ng Chao-Wei Lee Shu-Wei Huang Hsin-Chih Huang Tzung-Hai Yen
author_sort	Hao-Tsai Cheng
title	Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
title_short	Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
title_full	Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
title_fullStr	Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
title_full_unstemmed	Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
title_sort	profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e7cd30867f2444feb8388a9c11fca58e
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Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury.

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