A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of the DEAD-box protein Prp28.
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Nature Portfolio
2016
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oai:doaj.org-article:e7d1d18e40824533a67b9650add6c83c2021-12-02T15:35:44ZA spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity10.1038/ncomms119972041-1723https://doaj.org/article/e7d1d18e40824533a67b9650add6c83c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms11997https://doaj.org/toc/2041-1723The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of the DEAD-box protein Prp28.Carsten BoeslerNorbert RigoMaria M. AnokhinaMarcel J. TauchertDmitry E. AgafonovBerthold KastnerHenning UrlaubRalf FicnerCindy L. WillReinhard LührmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Carsten Boesler Norbert Rigo Maria M. Anokhina Marcel J. Tauchert Dmitry E. Agafonov Berthold Kastner Henning Urlaub Ralf Ficner Cindy L. Will Reinhard Lührmann A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| description |
The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of the DEAD-box protein Prp28. |
| format |
article |
| author |
Carsten Boesler Norbert Rigo Maria M. Anokhina Marcel J. Tauchert Dmitry E. Agafonov Berthold Kastner Henning Urlaub Ralf Ficner Cindy L. Will Reinhard Lührmann |
| author_facet |
Carsten Boesler Norbert Rigo Maria M. Anokhina Marcel J. Tauchert Dmitry E. Agafonov Berthold Kastner Henning Urlaub Ralf Ficner Cindy L. Will Reinhard Lührmann |
| author_sort |
Carsten Boesler |
| title |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| title_short |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| title_full |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| title_fullStr |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| title_full_unstemmed |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity |
| title_sort |
spliceosome intermediate with loosely associated tri-snrnp accumulates in the absence of prp28 atpase activity |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/e7d1d18e40824533a67b9650add6c83c |
| work_keys_str_mv |
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1718386506796630016 |