Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India

The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe vivax malaria in Gujarat, one of the main con...

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Autores principales:	Anupkumar R. Anvikar, Anna Maria van Eijk, Asha Shah, Kamlesh J. Upadhyay, Steven A. Sullivan, Ankita J. Patel, Jaykumar M. Joshi, Suchi Tyagi, Ranvir Singh, Jane M. Carlton, Himanshu Gupta, Samuel C. Wassmer
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	severe malaria plasmodium vivax gujarat india malaria elimination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e7d24da3b2d949c19350cec0f8c913d2
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spelling	oai:doaj.org-article:e7d24da3b2d949c19350cec0f8c913d22021-11-17T14:21:58ZClinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India2150-55942150-560810.1080/21505594.2020.1773107https://doaj.org/article/e7d24da3b2d949c19350cec0f8c913d22020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1773107https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe vivax malaria in Gujarat, one of the main contributors to the vivax malaria burden in the country, have been reported recently and may be the result of a decrease in transmission and immune development. Over a period of one year, we enrolled severe malaria patients admitted at the Civil Hospital in Ahmedabad, the largest city in Gujarat, to investigate the morbidity of severe vivax malaria compared to severe falciparum malaria. Patients were submitted to standard thorough clinical and laboratory investigations and only PCR-confirmed infections were selected for the present study. Severevivax malaria (30 patients) was more frequent than severe falciparum malaria (8 patients) in our setting, and it predominantly affected adults (median age 32 years, interquartile range 22.5 years). This suggests a potential age shift in anti-malarial immunity, likely to result from the recent decrease in transmission across India. The clinical presentation of severe vivax patients was in line with previous reports, with jaundice as the most common complication. Our findings further support the need for epidemiological studies combining clinical characterization of severe vivax malaria and serological evaluation of exposure markers to monitor the impact of elimination programmes.Anupkumar R. AnvikarAnna Maria van EijkAsha ShahKamlesh J. UpadhyaySteven A. SullivanAnkita J. PatelJaykumar M. JoshiSuchi TyagiRanvir SinghJane M. CarltonHimanshu GuptaSamuel C. WassmerTaylor & Francis Grouparticlesevere malariaplasmodium vivaxgujaratindiamalaria eliminationInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 730-738 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	severe malaria plasmodium vivax gujarat india malaria elimination Infectious and parasitic diseases RC109-216
spellingShingle	severe malaria plasmodium vivax gujarat india malaria elimination Infectious and parasitic diseases RC109-216 Anupkumar R. Anvikar Anna Maria van Eijk Asha Shah Kamlesh J. Upadhyay Steven A. Sullivan Ankita J. Patel Jaykumar M. Joshi Suchi Tyagi Ranvir Singh Jane M. Carlton Himanshu Gupta Samuel C. Wassmer Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
description	The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe vivax malaria in Gujarat, one of the main contributors to the vivax malaria burden in the country, have been reported recently and may be the result of a decrease in transmission and immune development. Over a period of one year, we enrolled severe malaria patients admitted at the Civil Hospital in Ahmedabad, the largest city in Gujarat, to investigate the morbidity of severe vivax malaria compared to severe falciparum malaria. Patients were submitted to standard thorough clinical and laboratory investigations and only PCR-confirmed infections were selected for the present study. Severevivax malaria (30 patients) was more frequent than severe falciparum malaria (8 patients) in our setting, and it predominantly affected adults (median age 32 years, interquartile range 22.5 years). This suggests a potential age shift in anti-malarial immunity, likely to result from the recent decrease in transmission across India. The clinical presentation of severe vivax patients was in line with previous reports, with jaundice as the most common complication. Our findings further support the need for epidemiological studies combining clinical characterization of severe vivax malaria and serological evaluation of exposure markers to monitor the impact of elimination programmes.
format	article
author	Anupkumar R. Anvikar Anna Maria van Eijk Asha Shah Kamlesh J. Upadhyay Steven A. Sullivan Ankita J. Patel Jaykumar M. Joshi Suchi Tyagi Ranvir Singh Jane M. Carlton Himanshu Gupta Samuel C. Wassmer
author_facet	Anupkumar R. Anvikar Anna Maria van Eijk Asha Shah Kamlesh J. Upadhyay Steven A. Sullivan Ankita J. Patel Jaykumar M. Joshi Suchi Tyagi Ranvir Singh Jane M. Carlton Himanshu Gupta Samuel C. Wassmer
author_sort	Anupkumar R. Anvikar
title	Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
title_short	Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
title_full	Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
title_fullStr	Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
title_full_unstemmed	Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India
title_sort	clinical and epidemiological characterization of severe plasmodium vivax malaria in gujarat, india
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/e7d24da3b2d949c19350cec0f8c913d2
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Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India

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